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Value of ultrasonic elastography, CEA, and CA125 in differential diagnosis of malignant breast nodules with rear echo attenuation |
WANG Yajing YUAN Juanjuan▲ |
Department of Ultrasound, Suzhou Hospital of Integrated Chinese and Western Medicine Mudu People’s Hospital of Suzhou, Jiangsu Province, Suzhou 215000, China |
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Abstract Objective To investigate the value of ultrasonic elastography, carcinoembryonic antigen (CEA), and carbohydrate antigen 125 (CA125) in differential diagnosis of malignant breast nodules with rear echo attenuation. Methods A total of 76 patients with rear echo attenuation breast nodules admitted to Suzhou Hospital of Integrated Chinese and Western Medicine, Jiangsu Province from May 2016 to February 2022 were selected. All patients underwent ultrasonic elastography. The ultrasonic elastography characteristics (strain ratio of fat/strain ratio of nodules [B/A], minimum elastic modulus [Emin], average elastic modulus [Emean], and maximum elastic modulus [Emax]) of benign and malignant breast nodules were compared; the levels of CEA and CA125 of benign and malignant breast nodules were compared; receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of ultrasound elastography, CEA, and CA125 in breast nodules with rear echo attenuation. Results Among 76 patients with breast nodules, 29 cases were malignant and 47 cases were benign. The diameter of malignant breast nodules was larger than that of benign nodules (P<0.05). B/A, Emean, and Emax of breast malignant nodules were higher than those of benign nodules (P<0.05); there was no significant difference in Emin between benign and malignant breast nodules (P>0.05). The levels of CEA and CA125 of malignant breast nodules were higher than that of benign nodules (P<0.05). The area under the curve of malignant breast nodules detected by B/A, Emean, Emax, CEA, and CA125 was higher than that detected by each index alone. Conclusion Ultrasound elastography (B/A, Emean, and Emax), CEA, and CA125 are important in the differential diagnosis of malignant breast nodules with rear echo attenuation.
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