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| Diagnostic value of functional magnetic resonance imaging combined with cortisol, homocysteine in type Ⅱ schizophrenia |
| QI Hongyang1 ZHOU Jie1 YANG Liming2 CHEN Jie3 WANG Lu4 CHENG Zusheng1▲ |
1.Department of Radiology, Shaoxing Seventh People’s Hospital, Zhejiang Province, Shaoxing 312000, China;
2.Department of Radiology, Shaoxing People’s Hospital, Zhejiang Province, Shaoxing 312000, China;
3.Department of Laboratory, Shaoxing Seventh People’s Hospital, Zhejiang Province, Shaoxing 312000, China;
4.Integrated Traditional Chinese and Western Medicine Sleep Disease Area, Shaoxing Seventh People’s Hospital, Zhejiang Province, Shaoxing 312000, China |
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Abstract Objective To analyze the diagnostic value of functional magnetic resonance imaging (fMRI) combined with cortisol and homocysteine (Hcy) in type Ⅱ schizophrenia. Methods Sixty patients with schizophrenia diagnosed at Shaoxing Seventh People’s Hospital (“our hospital” for short) from April 2021 to January 2022 were selected as the research group. Among them, 37 cases of type Ⅰ schizophrenia were the type I group, and 23 cases of type Ⅱ schizophrenia patients were the type Ⅱ group. Another 60 healthy individuals who underwent normal physical examinations in our hospital during the same period were selected as the control group. fMRI was performed and cortisol and Hcy were measured. The diagnostic value of fMRI combined with cortisol and Hcy in type Ⅱ schizophrenia were analyzed. Results The transverse diameter, left lateral crack width, and right lateral crack width of ventricle Ⅲ in type Ⅱ group were higher than those in control group and type Ⅰ group, and the thickness of corpus callosum was lower than those in control group and type Ⅰ group, and the differences were highly statistically significant (P＜0.05). There was no significant difference in fMRI indexes between group Ⅰ and control group (P＞0.05). The cortisol level of type Ⅱ group was significantly lower than that of control group and type Ⅰ group, and the differences were highly statistically significant (P＜0.01). There was no significant difference in cortisol level between group Ⅰ and control group (P＞0.05). The level of Hcy in type Ⅰ and type Ⅱ groups was higher than that in control group, and the level of Hcy in type Ⅱ group was significantly higher than that in type Ⅰ group, the differences were highly statistically significant (P＜0.01). The area under the curve value of fMRI combined with cortisol and Hcy in the diagnosis of type Ⅱ schizophrenia was higher than that of other tests alone. Conclusion fMRI examination results, cortisol, and Hcy abnormalities in patients with type Ⅱ schizophrenia, and the combination of fMRI and cortisol and Hcy detection can effectively improve the diagnostic value of negative schizophrenia.
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