Clinical evaluation of serum gastric function detection for warning of NSAIDS-related gastric hemorrhage
CHEN Minyan1 NIE Xinlai2 JIA Yuting1 MA Yun1 JIN Lingyan1
1.Health Management Center, the Second People’s Hospital of Jingdezhen, Jiangxi Province, Jingdezhen 333000, China; 2.Department of Neurology, the Second People’s Hospital of Jingdezhen, Jiangxi Province, Jingdezhen 333000, China
Abstract Objective To investigate the predictive value of serum gastric function indexes in patients with non-steroidal anti-inflammatory drugs (NSAIDs) related gastric hemorrhage. Methods A total of 191 patients with chronic diseases who received NSAIDs (Aspirin) in the Second People’s Hospital of Jingdezhen City, Jiangxi Province from May 2020 to May 2022 were selected as the study objects. According to the occurrence of gastric hemorrhage during three months of treatment, they were divided into bleeding group and no bleeding group. The levels of serum gastric function indexes before and after treatment were compared between the two groups. The influencing factors of gastric hemorrhage and the prediction effect of serum gastric function index on gastric hemorrhage were analyzed. Results The incidence of gastric hemorrhage within three months after NSAIDs treatment was 9.95%. There were statistically significant differences in age, history of alcoholism, history of digestive tract and, use of gastric mucosal protective agents between the two groups (P＜0.05). There were statistically significant differences in serum gastrin-17 (G-17), pepsinogen (PG) Ⅰ, PGⅡ, and PGⅠ/PGⅡ between the two groups (P＜0.05). After two months of treatment, the G-17 level in the bleeding group was lower than that before and after one month of treatment, and lower than that in the non-bleeding group. The levels of PGⅠ, PGⅡ, and PGⅠ/PGⅡ were higher than those before treatment and after one month of treatment, and higher than those in non-bleeding group, the differences were statistically significant (P＜ 0.05). Logistic regression analysis showed that age, history of alcoholism, history of digestive tract, gastric mucosal protective agents, serum G-7, PG-Ⅰ, PG-Ⅱ, and PG-Ⅰ/PG-Ⅱ levels after two months of treatment were all influential factors in the occurrence of gastric hemorrhage (P＜0.05). After two months of treatment, the AUC of serum G-17, PG-Ⅰ, PG-Ⅱ, and PG-Ⅰ/PG-Ⅱ combined predicted gastric hemorrhage was 0.879, which was higher than that predicted by any single index, and the differences were statistically significant (P＜0.05). Conclusion The different expression of serum gastric function index in patients with NSAIDs related gastric hemorrhage, combined detection of serum gastric function index has a certain predictive value for gastric hemorrhage.
CHEN Minyan1 NIE Xinlai2 JIA Yuting1 MA Yun1 JIN Lingyan1. Clinical evaluation of serum gastric function detection for warning of NSAIDS-related gastric hemorrhage[J]. 中国医药导报, 2023, 20(31): 101-105.
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