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| Research progress on the immune regulation function and mechanism of astragalus polysaccharides in bronchial asthma |
| CHEN Xi SHI Jinghong WU Shouzhen |
| College of Medical Technology, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China |
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Abstract The imbalance of immune cells and the cytokine “storm” it induces are the main driving factors for the occurrence and acute attack of bronchial asthma（“asthma” for short）, and the regulation of immune cell imbalance and cytokine“storm” is the fundamental treatment of asthma. Traditional Chinese medicine and its components have immune regulatory functions and can maintain the immune balance in vivo through various ways. Astragalus polysaccharides is the active ingredient of traditional Chinese medicine Huangqi, which has anti-inflammatory and immunomodulatory functions. Based on the interaction of astragalus polysaccharides receptors, this paper reviewed the molecular mechanisms of astragalus polysaccharides regulating MAPK and NF-κB signaling pathways, and comprehensively summarized its immunomodulatory effects and mechanisms in asthma, providing a theoretical basis for the clinical application of astragalus polysaccharides in asthma prevention and treatment, as well as a molecular basis for modern research on traditional Chinese medicine Huangqi.
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