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| Research progress on the mechanism of pulmonary hypertension and myocardial electrical remodeling |
| QIN Sirun CHEN Chenyang CAO Yu |
| Department of Cardiovascular Medicine, the Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China |
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Abstract Pulmonary arterial hypertension (PAH) is a disease that increases pulmonary arterial pressure and pulmonary vascular resistance leading to right ventricular failure (RVF) or even death of patients. RVF is the most common cause of death in patients with PAH. A large number of studies have shown that the process of RVF in PAH patients involves a series of myocardial remodeling, including cardiac structural remodeling, mechanical remodeling, and myocardial electrical remodeling, and myocardial electrical remodeling is an important cause of patients with malignant arrhythmia and sudden cardiac death. In recent years, there have been many studies on the molecular genetics and cell biology of PAH. This article reviews the upstream pathophysiological mechanism and the biological function and role of myocardial electrical remodeling in the pathogenesis of PAH, so as to provide new targets for the clinical treatment of PAH.
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