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| Analysis on the medication rule of Professor Gao Ronglin in the treatment of insomnia based on data mining |
| QI Leilei1 CHEN Yueying1 PANG Ran1 LIU Rui1 ZHANG Lijuan2 |
1.Department of Urology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
2.Department of Ultrasound, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China |
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Abstract Objective To analyze and summarize the medication rule of Professor Gao Ronglin in the treatment of insomnia based on data mining technology. Methods Medical records of insomnia patients in the outpatient department of Professor Gao Ronglin of Guang ’anmen Hospital, China Academy of Chinese Medical Sciences from October 2020 to October 2022 were selected. Microsoft Excel 2016 and Rstudio 4.2.1 statistical software were used to make statistics on the frequency, four natures, five flavours, channel tropism, and efficacy of drugs. Association rules and cluster analysis were performed for high-frequency drugs, and complex network visualization was performed using VOSviewer software. Results A total of 146 kinds of traditional Chinese medicine were involved in 358 prescriptions, and the cumulative use frequency was 4 947. Twenty kinds of traditional Chinese medicine, such as Ziziphi Spinosae Semen, Paeoniae Radix Alba, Polygalae Radix, and so on, were used more than 90 times. The four nature of drugs were mainly flat, warm, and cold, the five flavour of drugs were mainly sweet, bitter, and pungent, and the channel tropism of drugs were mainly liver, heart, and spleen. The most frequently used drugs were tonifying deficiency drugs and tranquillization drugs. The results of cluster analysis showed that the drug combinations with the highest support and frequency were Polygalae Radix-Ziziphi Spinosae Semen, followed by Moutan Cortex-Ziziphi Spinosae Semen, Coptidis Rhizoma-Ziziphi Spinosae Semen, and the drug combinations with the highest confidence were Cinnamomi Cortex-Ziziphi Spinosae Semen, Coptidis Rhizoma, Cinnamomi Cortex-Ziziphi Spinosae Semen. Cluster analysis could be divided into four categories. Conclusion Professor Gao Ronglin treats insomnia from liver, heart, and spleen, pays attention to treating the heart and regulating the spirit, regulating the spleen and stomach, and commonly uses Coptidis Rhizoma, Cinnamomi Cortex, and Ziziphi Spinosae Semen couplet medicines concerted application to communicate the mind, tonify the kidney and warm the yang.
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