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| Effect of longsha open and close pivot needle method combined with Letrozole in the treatment of infertility with polycystic ovarian syndrome |
| WEN Lina WANG Miao▲ ZHOU Yahong |
| Department of Reproductive Medicine, Wuxi Hospital of Traditional Chinese Medicine, Jiangsu Province, Wuxi 214072, China |
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Abstract Objective To explore the therapeutic effect of longsha open and close pivot needle method combined with Letrozole on infertility with polycystic ovary syndrome (PCOS). Methods A total of 84 infertility patients with PCOS admitted to Wuxi Hospital of Traditional Chinese Medicine, Jiangsu Province from June 2021 to October 2022 were selected, and they were divided into control group (received Letrozole treatment) and observation group (received longsha open and close pivot needle method combined with Letrozole treatment), with 42 cases in each group. The clinical efficacy of two groups were compared; ovulation rate and pregnancy rate of two groups were compared; ovarian volume, endometrial thickness, serum sex hormones (testosterone [T], estradiol [E2], luteinizing hormone [LH], follicle-stimulating hormone [FSH]) of two groups before and after treatment were compared; and the occurrence of adverse reactions during treatment was observed. Results The clinical efficacy of observation group was better than that of control group (P＜0.05). There was no difference in ovulation rate between two groups (P＞0.05); the pregnancy rate of observation group was higher than that of control group (P＜0.05). After treatment, the ovarian volume of two groups was lower than that before treatment, and the endometrial thickness was higher than that before treatment (P＜0.05); the ovarian volume of observation group was lower than that of control group, and the endometrial thickness was higher than that of control group (P＜0.05). After treatment, the serum T, LH, and FSH levels in two groups were decreased than those before treatment, while E2 levels were increased than those before treatment (P＜0.05); and the serum T, LH and FSH levels in observation group were lower than those of control group, while E2 levels were higher than those of control group (P＜0.05). There was no difference in the total incidence of adverse drug reactions between two groups (P＞0.05). Conclusion Longsha open and close pivot needle method combined with Letrozole in the treatment of infertility with PCOS can improve clinical efficacy, increase pregnancy rate, improve endometrial receptivity, regulate sex hormone levels, and is safe and reliable.
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