Abstract The occurrence and development of systemic lupus erythematosus（SLE） are regulated by epigenetic mechanisms, and histone modifications also play an important role in disease progression. SLE patients exhibit changes in histone modification patterns of autoreactive T cells and B cells, including methylation (CREMα, CXCR5, HPK1, EZH2, TNFAIP3, BACH2, etc.), acetylation (BCL-6, BACH2, IL-2/10/17, etc.), phosphorylation, ubiquitination, etc. And these changes may be caused by changes in the level of specific histone modifying enzymes, while the role of histone modifying enzymes and changes in histone modifying levels in SLE is currently in the exploratory stage. This article provides a brief overview of the research progress of histone modification in SLE, and introduces therapeutic drugs targeting epigenetic targets.
MIAO Lin WANG Qingcui CHEN Xiaohua. Research progress on the role of histone modification in the pathogenesis of systemic lupus erythematosus[J]. 中国医药导报, 2023, 20(30): 68-71.
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