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| Research progress of liquid biopsy in the neoadjuvant treatment of rectal cancer |
| ZHAO Yunlin HUANG Shi KE Shuhui LIN Dandan |
| Cancer Center, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China |
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Abstract Liquid biopsy is an emerging detection technique with the advantages of being less invasive, highly specific, and avoiding tumor heterogeneity and it used in early screening, efficacy assessment, and recurrence monitoring of tumors. For patients with low to intermediate locally advanced rectal cancer (LARC) receiving neoadjuvant therapy, determining the efficacy of neoadjuvant therapy and monitoring tumor recurrence determines treatment options. Several studies demonstrate that liquid biopsy can predict the effectiveness of neoadjuvant treatment in patients with LARC, monitor tumor recurrence earlier than tumor markers such as carcinoembryonic antigen and imaging, and show the long-term survival prognosis of patients, thus providing a more personalized treatment strategy for patients with LARC receiving neoadjuvant therapy. This article reviews and summarizes the use of liquid biopsy in the neoadjuvant treatment of LARC, focusing on several indicators in liquid biopsy.
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