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Research progress of traditional Chinese medicine on the comorbidity of psoriasis and diabetes mellitus |
ZHANG Ning1 ZHANG Qiong2 YANG Suqing2 AN Yuepeng2 |
1.Graduate School, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China; 2.Department of Dermatology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Psoriasis belongs to the category of “white crust” in traditional Chinese medicine, and diabetes mellitus is called “consumptive thirst” in traditional Chinese medicine. Psoriasis is more likely to be associated with diabetes mellitus in clinic, which makes the condition complicated. It has a broad development prospect to take traditional Chinese medicine as a starting point to treat the comorbidity. From the perspective of western medicine, this article briefly describes that psoriasis and diabetes mellitus have significant correlation in modern biological basis and risk factors. From the perspective of traditional Chinese medicine, by summarizing the understanding of various medical experts, it can be concluded that dampness evil is at the beginning of the onset, blood stasis runs through the entire process, and later the body’s qi and yin are damaged, “dampness, stasis, and deficiency” are the key causes and pathogenesis of both comorbidities. This paper also expounds the characteristics of traditional Chinese medicine syndrome differentiation in the treatment of psoriasis and diabetes mellitus, in order to better guide clinical practice and give full play to the characteristics of traditional Chinese medicine treatment.
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[1] Mamizadeh M,Tardeh Z,Azami M. The association between psoriasis and diabetes mellitus:a systematic review and meta- analysis [J]. Diabetes Metab Syndr,2019,13(2):1405-1412. [2] Wan MT,Shin DB,Hubbard RA,et al. Psoriasis and the risk of diabetes:aprospective population-based cohort study [J]. J Am Acad Dermatol,2018,78(2):315-322. [3] Micali G,Lacarrubba F,Musumeci ML,et al. Cutaneous vascular patterns in psoriasis [J]. Int J Dermatol,2010,49(3):249-256. [4] Ribeiro CF,Siqueira EB,Holler AP,et al. Periungual capillaroscopy in psoriasis [J]. An Bras Dermatol,2012,87(4):550-553. [5] ?覫stergaard L,Finnerup NB,Terkelsen AJ,et al. The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy [J]. Diabetologia,2015,58(4):666-677. [6] 高雁鸿,刘建志,王仁山,等.血管内皮细胞功能与糖尿病的关系研究进展[J].山西大同大学学报(自然科学版),2020,36(4):50-54,66. [7] 费文敏,汤华阳,杨森,等.银屑病皮肤微循环改变研究进展[J].中国皮肤性病学杂志,2018,32(6):714-717. [8] Wolk K,Sabat R. Adipokines in psoriasis:an important link between skin inflammation and metabolic alterations [J]. Rev Endocr Metab Disord,2016,17(3):305-317. [9] Brazlli V,Muaffoi P,Bolcato V,et al. Psoriasis and diabetes,a dangerous association:evaluation of insulin resistance,lipid abnormalities,and cardiovascular risk biomarkers [J]. Front Med (Lausanne),2021,8:605691. [10] Gerdes S,Rostami-yazdi M,Mrowietz U. Adipokines and psoriasis [J]. Exp Dermatol,2011,20(2):81-87. [11] 刘晓涵,晋红中.银屑病复发的危险因素及机制[J].协和医学杂志,2022,13(2):308-314. [12] Xu X,Lin L,Chen P,et al. Treatment with liraglutide,a glucagon-like peptide-1 analogue,improves effectively the skin lesions of psoriasis patients with type 2 diabetes:a prospective cohort study [J]. Diabetes Res Clin Pract,2019, 150:167-173. [13] Lynch M,Malara A,Timoney I,et al. Sitagliptin and narrow-band ultraviolet-B for moderate psoriasis (DINUP):a randomised controlled clinical trial [J]. Dermatology,2022, 238(1):140-147. [14] Tsuji G,Hashinoto-Hachiya A,Yen VH,et al. Metformin inhibits IL-1β secretion via impairment of NLRP3 infammasome in keratinocytes:implications for preventing the development of psoriasis [J]. Cell Death Discov,2020,6:11. [15] 朱世飞,周里钢.2型糖尿病合并银屑病研究进展[J].辽宁中医药大学学报,2019,21(4):80-83. [16] 郭小舟,陶夏平,王斌.从湿热瘀毒论治糖尿病[J].中国中医基础医学杂志,2021,27(6):1017-1018,1021. [17] 晏娟,刘剑辉,邹佳华,等.银屑病与代谢综合征中西医相关性探讨[J].中医药临床杂志,2022,34(5):815-819. [18] 张晓彤,高云逸,宋坪.寻常型银屑病中医辨证特点概况及思考[J].中医杂志,2019,60(20):1732-1736. [19] 戈旦,闵仲生.银屑病合并代谢综合征的中医病因病机[J].吉林中医药,2016,36(6):549-552. [20] 李兰芝,徐丽梅.2型糖尿病合并皮肤病变的中医症候学研究[J].解放军医药杂志,2020,32(2):88-92. [21] 李欣,李洪锦,孙晓颖,等.银屑病合并糖代谢紊乱中医病机解析[J].世界临床药物,2019,40(11):747-751. [22] 杨颖,魏梦昕,伍耀业,等.白术多糖提取分离、化学组成和药理作用的研究进展[J].中草药,2021,52(2):578-584. [23] 程玥,丁泽贤,张越,等.茯苓多糖及其衍生物的化学结构与药理作用研究进展[J].中国中药杂志,2020,45(18):4332-4340. [24] 李娜,张晨,钟赣生,等.不同品种甘草化学成分、药理作用的研究进展及质量标志物(Q-Marker)预测分析[J].中草药,2021,52(24):7680-7692. [25] 孔祥阳,李忻红.《医宗金鉴》名方治疗银屑病应用现状[J].山西中医,2020,36(4):59-60,62. [26] 徐坤元,姚晨思,李敏.基于“态靶因果”探讨2型糖尿病用药策略[J].中华中医药杂志,2021,36(9):5372- 5376. [27] 刘丽娟,吴亚运,赵亚,等.土茯苓、乌梅及其配伍对银屑病样模型小鼠皮损组织炎症因子及Notch信号通路的影响[J].中医杂志,2022,63(19):1880-1887. [28] 刘思佳,姚杰,宋雪,等.苍术属药用植物的化学成分、药理作用、临床应用概况[J].中华中医药学刊,2023,41(1):151-154. [29] 魏巍,吴疆,郭章华.南沙参的化学成分和药理作用研究进展[J].药物评价研究,2011,34(4):298-300. [30] 邱晓月,景永帅,郑玉光,等.北沙参多糖对免疫系统调节作用研究进展[J].中国药理学与毒理学杂志,2021, 35(10):794. [31] 彭婉,马骁,王建,等.麦冬化学成分及药理作用研究进展[J].中草药,2018,49(2):477-488. [32] 向聪莲,陈海明,黎莉,等.桃红四物汤治疗银屑病的网络药理学作用机制[J].中药新药与临床药理,2020,31(6):685-693. [33] 吕景娣,苗艳艳,苗明三.单味中药降血糖作用特点分析[J].中医学报,2012,27(10):1314-1318. [34] 张凡,王绾江,景慧玲.紫草的现代药理研究及皮肤科中的应用[J].中医药导报,2020,26(9):168-172. [35] 何泽源,张妍妍,林楠,等.赤芍化学成分和药理作用及质量标志物的预测分析[J].中药材,2020,43(12):3074- 3079. [36] 孙婧,杨燕云,许亮,等.鬼箭羽化学成分与药理作用研究进展[J].辽宁中医药大学学报,2021,23(7):85-95. [37] 孙艺榕,安月鹏.杨素清教授应用对药治疗银屑病的经验采撷[J].环球中医药,2017,10(6):758-760. [38] 顾剑萍,林乾良.乌梢蛇的药理研究初报[J].浙江药学,1986(4):4-8. [39] 牛巧丽,张媛,张娟.张娟主任医师治疗糖尿病并发银屑病经验[J].甘肃中医学院学报,2009,26(6):1-3. |
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