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| Effect of adjuvant therapy with Fuling Sini Decoction on organ function and inflammation response in patients with severe sepsis after continuous blood purification treatment |
| ZHU Yingxi GU Xian QIN Bing |
| Department of Critical Care Medicine, Taicang Traditional Chinese Medicine Hospital, Jiangsu Province, Taicang 215400, China |
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Abstract Objective To study the effect of adjuvant therapy with Fuling Sini Decoction on organ function and inflammation response in patients with severe sepsis after continuous blood purification treatment. Methods A total of 88 patients with severe sepsis in the Department of Critical Care Medicine, Taicang Traditional Chinese Medicine Hospital, Jiangsu Province from December 2017 to December 2021 were selected and they were divided into control group and observation group according to random number table method, with 44 patients in each group. The control group was treated with continuous blood purification, and the observation group was treated with Fuling Sini Decoction on the basis of the control group. The efficacy of the two groups was compared, and the traditional Chinese medicine syndrome score, organ function (glutamic-pyruvic transaminase [GPT], glutamic-oxaloacetic transaminase [GOT], total bilirubin [TB], serum creatinine [SCr], blood urea nitrogen [BUN], uric acid [UA], left ventricular ejection fraction [LVEF], left ventricular end diastolic diameter [LVEDD], left ventricular end systolic diameter [LVESD]), inflammatory response (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α], white blood cell count [WBC], C-reactive protein [CRP]) before and after three days of treatment were compared and mechanical ventilation time and hospital stay were counted. Results After three days of treatment, traditional Chinese medicine syndrome scores of both groups were decreased, and those of observation group was lower than those of control group (P＜0.05). The curative effect of observation group was better than that of control group (P＜0.05). After three days of treatment, GPT, GOT, TB, LVEDD, LVESD, SCr, BUN, and UA in both groups were lower than before treatment, and LVEF was higher than before treatment, and GPT, GOT, TB, LVEDD, LVESD, SCr, BUN, and UA in observation group were lower than control group, and LVEF was higher than control group (P＜0.05). After three days of treatment, serum levels of IL-6, TNF-α, WBC, and CRP in both groups were decreased, and those in observation group was lower than those in control group (P＜0.05). Mechanical ventilation time and hospital stay in observation group were shorter than those in control group (P＜0.05). Conclusion Fuling Sini Decoction with continuous blood purification is effective in the treatment of severe sepsis. It can reduce traditional Chinese medicine syndrome score, improve organ function, reduce inflammation response, shorten mechanical ventilation time and hospital stay.
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