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| Effect of Yisui Fuyong Decoction on dementia under the theory of “treating encephalopathy with yin constitution based on warming yang method” |
| TANG Guohua ZHU Jianwei TAO Wenqiang |
| The Fourth Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chongqing 402682, China |
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Abstract Objective To investigate the effect of Yisui Fuyong Decoction on dementia under the theory of “treating encephalopathy with yin constitution based on warming yang method”. Methods A total of 78 patients with senile dementia admitted to The Fourth Clinical Medical College, Chengdu University of Traditional Chinese Medicine from July 2020 to July 2022 were selected and they were divided into treatment group and control group according to random number table method, with 39 cases in each group. The control group was given Donepezil Hydrochloride Tablets, and the treatment group was given Yisui Fuyong Decoction on the basis of the control group. Both groups were treated for six months. The mini mental status examination (MMSE), Barthel index, serum homocysteine (Hcy), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), traditional Chinese medicine symptom score were compared between the two groups before and after treatment and clinical effect was compared after treatment. Results After treatment, MMSE and Barthel index scores in both groups were higher than before treatment, and those in the treatment group were higher than those in the control group, the differences were statistically significant (P＜0.05). After treatment, the levels of Hcy, TNF-α, and IL-6 in two groups were lower than before treatment, and the levels of TNF-α and IL-6 in treatment group were lower than those in control group, the differences were statistically significant (P＜0.05). There was no significant difference in Hcy level between the two groups (P＞0.05). After treatment, the traditional Chinese medicine symptom score of the two groups was lower than that before treatment, and that of the treatment group was lower than that of the control group, the differences were statistically significant (P＜0.05). The therapeutic effect of the treatment group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Under the theory of “treating encephalopathy with yin constitution based on warming yang method”, Yisui Fuyong Decoction can improve the effect of dementia and improve the clinical symptoms of patients, which is worthy of clinical application.
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