血清可溶性肿瘤坏死因子相关凋亡诱导配体、半乳凝素3、摄食抑制因子-1与慢性阻塞性肺疾病合并抑郁的相关性分析

doi:10.20047/j.issn1673-7210.2023.29.26

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Abstract Objective To investigate the correlation of serum soluble tumor necrosis factor-associated apoptosis-inducing ligand (sTRAIL), galectin-3, nesfatin-1 with chronic obstructive pulmonary disease (COPD) complicated with depression. Methods A total of 173 hospitalized patients with acute exacerbation of COPD admitted to the First Affiliated Hospital of Hebei North University from July 2019 to May 2021 were selected, including 103 patients in the simple COPD group and 70 patients in the COPD combined with depression group. Clinical data and serum levels of sTRAIL, galectin-3, and nesfatin-1 of the two groups were recorded and compared. Logistic regression model was used to analyze the influencing factors of COPD combined with depression, and receiver operating characteristic (ROC) curve was further drawn to evaluate the prediction efficiency. Results The COPD assessment test score, the proportion of poor treatment compliance, the proportion of chronic diseases, the proportion of patients living alone, and the serum levels of sTRAIL, galectin-3, and nesfatin-1 in the COPD combined with depression group were higher than those in the simple COPD group, the percentage of forced expiratory volume in first second to forced vital capacity (FEV1/FVC), the percentage of forced expiratory volume in the first second to the expected value (FEV1pred), and the proportion of employees medical insurance in the COPD combined with depression group were lower than those in the simple COPD group, and the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that FEV1/FVC, FEV1pred, treatment compliance, medical insurance type, and serum sTRAIL, galectin-3, and nesfatin-1 were the influencing factors of COPD combined with depression (P＜0.05). ROC curve analysis showed that serum sTRAIL, galectin-3, and nesfatin-1 alone and in combination had certain predictive value for COPD complicated with depression (P＜0.05). Conclusion Depression in patients with COPD is associated with a variety of factors, serum sTRAIL, galectin-3, and nesfatin-1 joint detection merge depression in patients with COPD diagnosis has a certain value.

Key words： Chronic obstructive pulmonary disease Depression Soluble tumor necrosis factor-related apoptosis-inducing ligand Galectin-3 Nesfatin-1

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	ZHANG Changhong ZHANG Zhihua JI Zexuan

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ZHANG Changhong ZHANG Zhihua JI Zexuan. Correlation analysis of serum soluble tumor necrosis factor-related apoptosis-inducing ligand, galectin-3, nesfatin-1, and chronic obstructive pulmonary disease complicated with depression[J]. 中国医药导报, 2023, 20(29): 116-120.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.29.26 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I29/116

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