Effect of Vitamin AD Drops combined with glucocorticoid inhalation in the treatment of mycoplasma pneumonia in children and its effect on immune function
JANG Yuanyuan1 PAN Jianrong2 ZHANG Heng3▲
1.Department of Pediatric Internal Medicine, Wuxi Maternal and Child Health Care Hospital Wuxi School of Medical, Jiangnan University, Jiangsu Province, Wuxi 214002, China; 2.Department of Pediatric Respiratory, Wuxi Children’s Hospital, Jiangsu Province, Wuxi 214000, China; 3.Department of Child Healthcare, Wuxi Maternal and Child Health Care Hospital Wuxi School of Medical, Jiangnan University, Jiangsu Province, Wuxi 214002, China
Abstract Objective To observe the effect of Vitamin AD Drops combined with glucocorticoid inhalation in the treatment of mycoplasma pneumonia in children and its effect on immune function. Methods A total of 92 children with mycoplasma pneumonia in children admitted to Wuxi Maternal and Child Health Hospital, Jiangsu Province from January 2018 to October 2019 were selected as study subjects. They were divided into two groups by odd-even number labeling method, with 46 cases in each group. Both groups were treated with Azithromycin, the glucocorticoid group were treated with inhalation glucocorticoid, and combined group were treated with Vitamin AD Drops based on glucocorticoid group, the course of treatment was two weeks. The clinical effect of two groups was compared; symptoms and signs improvement time, immune function, regulatory T cells/helper T cells 17 (Treg/Th17) were compared between two groups; patients were followed up for one year and the recurrence was recorded in both groups. Results In glucocorticoid group, three cases were shed, and 43 cases were enrolled. The disappearance time of fever, asthma, cough, and wet rales in combination group was shorter than that in glucocorticoid group (P＜0.05); there was no significant difference in the time of lung shadow disappearance between two groups (P＞0.05). After treatment, CD3+, CD4+, and CD4+/CD8+ in both groups were higher than those before treatment, and CD8+ was lower than that before treatment, and CD3+, CD4+, and CD4+/CD8+ in combination group were higher than those in glucocorticoid group, and CD8+ was lower than that in glucocorticoid group (P＜0.05). After treatment, Treg and Treg/Th17 were higher than those before treatment, and Th17 was lower than that before treatment, and Treg and Treg/Th17 in combination group were higher than those in glucocorticoid group, and Th17 was lower than that in glucocorticoid group (P＜0.05). There was no significant difference in clinical efficacy between two groups (P＞0.05). The recurrence rate of combined group was lower than that of glucocorticoid group, and the treatment time when recurrence was shorter than that of glucocorticoid group (P＜0.05). Conclusion Vitamin AD Drops combined with glucocorticoids can promote the disappearance of symptoms and signs and reduce recurrence of mycoplasma pneumonia in children, which may be related to the regulation of immune function.
JANG Yuanyuan1 PAN Jianrong2 ZHANG Heng3▲. Effect of Vitamin AD Drops combined with glucocorticoid inhalation in the treatment of mycoplasma pneumonia in children and its effect on immune function[J]. 中国医药导报, 2023, 20(29): 99-102.
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