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| Effect of Raloxifene on negative symptoms, cognitive function, and quality of life in menopausal patients with chronic schizophrenia |
| ZHU Ming ZHANG En XU Ying |
| Department of Psychiatry, Wuhu Fourth People’s Hospital, Anhui Province, Wuhu 241000, China |
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Abstract Objective To study the effect of Raloxifene on negative symptoms, cognitive function, and quality of life in menopausal patients with chronic schizophrenia. Methods A total of 80 postmenopausal female schizophrenics with negative symptoms and long-term treatment with Clozapine from the outpatient department of Wuhu Fourth People’s Hospital, Anhui Province from January 2021 to January 2022 were selected as the research object. According to random number table method, they were divided into control group (40 cases) and study group (40 cases). The control group was treated with Clozapine, and the research group was treated with Clozapine and Raloxifene, the treatment lasted for 12 weeks. The positive and negative symptom scale (PANSS) score, scale for assessment of negative symptoms (SANS) score, serum estradiol (E2) levels, the repeatable battery for the assessment of neuropsychological status (RBANS) score, and generic quality of life inventory-74 (GQOLI-74) score were compared between two groups before and after treatment; the occurrence of adverse reactions during treatment was observed. Results After treatment, the SANS score and PANSS score of two groups were lower than those before treatment, and those in study group were higher than those in control group (P＜0.05), and the E2 level of two groups was higher than that before treatment, and that in study group was higher than that in control group (P＜0.05). After treatment, the scores of immediate memory, attention, verbal function, delayed memory, and visual span in two groups were higher than those before treatment, and those in study group were higher than those in control group (P＜0.05). After treatment, the scores of material life status, social function, physical function, and psychological function of two groups were higher than those before treatment, and those in study group were higher than those in control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion Raloxifene can effectively relieve the negative symptoms of menopausal patients with chronic schizophrenia, improve the quality of life and cognitive function of patients, and has high safety.
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