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| Expression of TIPE2, Ki-67 in endometrial cancer tissues and their relationship with pathological features |
| ZHOU Liyuan1 SHI Zhe2 LIU Yuejun1 LIU Mingyue3 GUO Xiaohui4 HAO Xufeng5 LI Jingxia1 AN Xin6 |
1.Department of Gynecology, Affiliated Hospital of Hebei Engineering University, Hebei Province, Handan 056002, China;
2.Department of General Surgery, Affiliated Hospital of Hebei Engineering University, Hebei Province, Handan 056002, China;
3.Department of Oncology, Handan Central Hospital, Hebei Province, Handan 056002, China;
4.Department of General Surgery, Handan Central Hospital, Hebei Province, Handan 056002, China;
5.Ward One, Department of Gynecology, Hebei Provincial Cixian People’s Hospital, Hebei Province, Handan 056002, China;
6.Department of Pathology, Handan First Hospital, Hebei Province, Handan 056002, China |
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Abstract Objective To analyze the expression of TIPE2 and Ki-67 in the tissues of patients with endometrial cancer and their relationship with pathological features. Methods From January 2018 to January 2020, 60 patients with endometrial cancer treated in the Affiliated Hospital of Hebei Engineering University (hereinafter referred to as “our hospital”) were selected as case group, and another 60 patients with endometrial atypical hyperplasia treated in our hospital during the same period were selected as control group. The expression levels of TIPE2 and Ki-67 were compared between two groups; the expression levels of TIPE2 and Ki-67 in endometrial carcinoma patients with different pathological characteristics were compared; and the correlation of the expression of TIPE2 and Ki-67 with pathological features was analyzed. Results The negative rate of TIPE2 and the positive rate of Ki-67 in case group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The negative rate of TIPE2 and the positive rate of Ki-67 in patients with endometrial cancer were statistically significant in different Federation International of Gynecology and Obstetrics (FIGO) stages, histological grades, degree of muscular invasion, and lymph node metastasis (P＜0.05); there were no significant differences in the negative rate of TIPE2 and the positive rate of Ki-67 with different pathological types and tumor diameters in patients with endometrial cancer (P＞0.05). The expression of TIPE2 negative and Ki-67 positive were positively correlated with FIGO stage, histological grade, degree of muscle infiltration, and lymph node metastasis (rs＞0, P＜0.05). Conclusion The negative rate of TIPE2 and the positive rate of Ki-67 in patients with endometrial carcinoma is high, which can be used to evaluate the potential of invasion and metastasis, pathological stage, and histological grade of cancer cells.
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