负压封闭引流技术结合高压氧治疗难治性压疮的效果

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Abstract Objective To investigate the efficacy of vacuum sealing drainage (VSD) combined with hyperbaric oxygen in treating refractory bedsore. Methods From January 2016 to December 2017, in Beijing Fengsheng Special Hospital of Traditional Medical Traumatology and Orthopaedics and Navy General Hospital, the clinical data of 37 patients with Ⅲ and Ⅳ degree bedsores was retrospectively analyzed, 20 cases were treated with VSD only (regarded as VSD group), 17 cases were treated with VSD combined with hyperbaric oxygen (regarded as VSD combined with HBO group), patients of both groups had the same basic nursing plan. At 2 weeks, 3 weeks, 1 month after treatment, specimens of wound from two groups were taken respectively, the CD34 immunohistochemistry was performed by streptavidine-biotin complex (SABC), the number of wild vascular cross was observed as capillary density value under high magnification microscope to assess the hyperplasia of granulation tissues of wound. The capillary density value and the visual wound observation were indicators for evaluation of clinical efficacy. Results The capillary density of VSD combined with HBO group was higher than that of VSD group at each time point, the differences were statistically significant (P < 0.05). Compared with the VSD group, the VSD combined with HBO group had higher effective rate and less average time, the differences were statistically significant (P < 0.05). Conclusion VSD combined with hyperbaric oxygen can effectively promote the rapid growth of new granulation tissue. It has good curative effect and short course of treatment, and provides a new strategy for clinical treatment of refractory bedsore.

Key words： Vacuum sealing drainage Hyperbaric oxygen Refractory bedsore Effect

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	SHEN Chen1 GUO Dazhi2▲

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SHEN Chen1 GUO Dazhi2▲. Effect of hyperbaric oxygen combined with vacuum sealing drainage for treating refractory bedsore[J]. 中国医药导报, 2018, 15(32): 106-108,117.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I32/106

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