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Effect of prone position ventilation in children with PICU ventilator-associated pneumonia#br# |
LIN Lingjie ZHANG Danru DONG Miaomiao |
Department of Pediatric Intensive Care Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou 325000, China
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Abstract Objective To analyze the effect of prone position ventilation in children with ventilator-associated pneumonia in pediatric intensive care unit (PICU). Methods A total of 120 children with PICU admitted to the Second Affiliated Hospital of Wenzhou Medical University from December 2020 to July 2022 were selected. They were divided into study group (60 cases) and experimental group (60 cases) in alternating order of using mechanical ventilation. The body position was changed every two to three hours, the control group was replaced by supine position and side position, while the experimental group was replaced by supine position, side position and prone position. The incidence of complications, lung function, levels of inflammatory factors, and clinical efficacy of two groups were detected and compared. Results After treatment, the maximum volume of air, forced expiratory volume in one second, forced vital capacity, and maximum expiratory flow in experimental group were higher than those in control group, and the differences were statistically significant (P<0.05). The levels of transforming growth factor-β1, interleukin-6, high mobility group protein box1, and tumor necrosis factor-α in experimental group were lower than those in control group, and the differences were statistically significant (P<0.05). The total complication rate in experimental group was lower than that in control group, and the difference was statistically significant (P<0.05). The total effective rate of treatment in experimental group was higher than that in control group, and the difference was statistically significant (P<0.05). Conclusion After prone position ventilation in PICU, the incidence of ventilator-associated pneumonia is reduced, lung function is improved, inflammation is alleviated, and symptoms are relieved.
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