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| Association of cognitive function with immune biomarkers and comprehensive inflammatory scores in adolescents with unipolar and bipolar depressive disorder |
| SHENG Dongfang1 YANG Fan2 ZHONG Jing3 YU Jinming4 CHEN Yihua4 DU Baoguo4 XU Mingzhi2▲ |
1.The Second Clinical Medical College, Southern Medical University, Guangdong Province, Guangzhou 510260, China;
2.Guangdong Mental Health Center, Guangdong Provincial People’s Hospital of Southern Medical University Guangdong Academy of Medical Sciences, Guangzhou Province, Guangdong 510180, China;
3.School of Public Health, Southern Medical University, Guangdong Province, Guangzhou 510515, China;
4.Department of Emotional Disorder, Zhongshan Third People’s Hospital, Guangdong Province, Zhongshan 528451, China
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Abstract Objective To explore the correlation between cognitive function, immune biomarkers and inflammation score in adolescents with unipolar and bipolar depressive disorder. Methods A total of 58 adolescent patients with unipolar depressive disorder (unipolar group) and 41 patients with bipolar depressive disorder (bipolar group) admitted to Guangdong Provincial People’s Hospital and Zhongshan Third People’s Hospital of Guangdong Province from December 2020 to December 2021 were included. Clinical data of two groups were collected, and the cognitive function was assessed by Stroop color-word test, Wisconsin card sorting test (WCST), and digital span test (DST). Fasting venous blood of the two groups was collected, C-reactive protein levels, platelet, white blood cell, granulocyte, and lymphocyte counts were detected, and immune biomarkers and comprehensive inflammatory scores were calculated. Clinical data, cognitive function, and immune biomarkers and comprehensive inflammatory score were compared between the two groups to analyze the association between cognitive function and immune biomarkers and comprehensive inflammatory score in adolescents with unipolar and bipolar depression. Results The incidence age, frequency of attacks, and positive family history in bipolar group were higher than those in unipolar group, and the course of disease was longer than that in unipolar group, the differences were statistically significant (P＜0.05). The correct number of Stroop color-word test, the percentage of correct WCST response, and the DST score in the bipolar group were lower than those in the unipolar group, while the number of Stroop color-word test errors, the number of responses required for WCST to complete the first classification, and the immune biomarkers and comprehensive inflammatory score were higher than those in the unipolar group, the differences were statistically significant (P＜0.05). Correlation analysis showed that the number of Stroop color-word test errors was positively correlated with immune biomarkers and comprehensive inflammatory scores (rs＞0, P＜0.05), and the percentage of correct WCST response in the bipolar group were negatively correlated with immune biomarkers and comprehensive inflammatory scores (r＜0, P＜0.05). Conclusion Cognitive impairment and inflammatory changes in adolescents with bipolar depression were more severe than those with unipolar depression, and cognitive function was correlated with immune biomarkers and comprehensive inflammatory scores in bipolar depression.
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