Association of cognitive function with immune biomarkers and comprehensive inflammatory scores in adolescents with unipolar and bipolar depressive disorder
SHENG Dongfang1 YANG Fan2 ZHONG Jing3 YU Jinming4 CHEN Yihua4 DU Baoguo4 XU Mingzhi2▲
1.The Second Clinical Medical College, Southern Medical University, Guangdong Province, Guangzhou 510260, China;
2.Guangdong Mental Health Center, Guangdong Provincial People’s Hospital of Southern Medical University Guangdong Academy of Medical Sciences, Guangzhou Province, Guangdong 510180, China;
3.School of Public Health, Southern Medical University, Guangdong Province, Guangzhou 510515, China;
4.Department of Emotional Disorder, Zhongshan Third People’s Hospital, Guangdong Province, Zhongshan 528451, China
Abstract Objective To explore the correlation between cognitive function, immune biomarkers and inflammation score in adolescents with unipolar and bipolar depressive disorder. Methods A total of 58 adolescent patients with unipolar depressive disorder (unipolar group) and 41 patients with bipolar depressive disorder (bipolar group) admitted to Guangdong Provincial People’s Hospital and Zhongshan Third People’s Hospital of Guangdong Province from December 2020 to December 2021 were included. Clinical data of two groups were collected, and the cognitive function was assessed by Stroop color-word test, Wisconsin card sorting test (WCST), and digital span test (DST). Fasting venous blood of the two groups was collected, C-reactive protein levels, platelet, white blood cell, granulocyte, and lymphocyte counts were detected, and immune biomarkers and comprehensive inflammatory scores were calculated. Clinical data, cognitive function, and immune biomarkers and comprehensive inflammatory score were compared between the two groups to analyze the association between cognitive function and immune biomarkers and comprehensive inflammatory score in adolescents with unipolar and bipolar depression. Results The incidence age, frequency of attacks, and positive family history in bipolar group were higher than those in unipolar group, and the course of disease was longer than that in unipolar group, the differences were statistically significant (P＜0.05). The correct number of Stroop color-word test, the percentage of correct WCST response, and the DST score in the bipolar group were lower than those in the unipolar group, while the number of Stroop color-word test errors, the number of responses required for WCST to complete the first classification, and the immune biomarkers and comprehensive inflammatory score were higher than those in the unipolar group, the differences were statistically significant (P＜0.05). Correlation analysis showed that the number of Stroop color-word test errors was positively correlated with immune biomarkers and comprehensive inflammatory scores (rs＞0, P＜0.05), and the percentage of correct WCST response in the bipolar group were negatively correlated with immune biomarkers and comprehensive inflammatory scores (r＜0, P＜0.05). Conclusion Cognitive impairment and inflammatory changes in adolescents with bipolar depression were more severe than those with unipolar depression, and cognitive function was correlated with immune biomarkers and comprehensive inflammatory scores in bipolar depression.
SHENG Dongfang1 YANG Fan2 ZHONG Jing3 YU Jinming4 CHEN Yihua4 DU Baoguo4 XU Mingzhi2▲. Association of cognitive function with immune biomarkers and comprehensive inflammatory scores in adolescents with unipolar and bipolar depressive disorder[J]. 中国医药导报, 2023, 20(28): 115-118,131.
[1] Shorey S，Ng ED，Wong CHJ. Global prevalence of depression and elevated depressive symptoms among adolescents：A systematic review and meta-analysis [J]. Br J Clin Psychol，2022，61（2）：287-305.
[2] Serra G，De Crescenzo F，Maisto F，et al. Suicidal behavior in juvenile bipolar disorder and major depressive disorder patients：Systematic review and meta-analysis [J]. J Affect Disord，2022，311：572-581.
[3] 赵媛媛，赵晓川，谭莉，等.双相情感障碍抑郁发作与单相抑郁症患者执行功能损害的对照研究[J].临床荟萃，2014，29（7）：769-770，774.
[4] 狄东川，赵凤霞，许允帅，等.双相抑郁与单相抑郁患者认知功能的比较[J].中国健康心理学杂志，2022，30（5）：641-644.
[5] 余姝，王强，邓伟，等.双相障碍抑郁发作与重性抑郁障碍患者认知功能损害比较[J].临床精神医学杂志，2021， 31（2）：130-133.
[6] Bulut NS，Yorguner N，■arkaxhiu Bulut G. The severity of inflammation in major neuropsychiatric disorders：comparison of neutrophil-lymphocyte and platelet-lymphocyte ratios between schizophrenia，bipolar mania，bipolar depression，major depressive disorder，and obsessive compulsive disorder [J]. Nord J Psychiatry，2021，75（8）：624-632.
[7] Wang AK，Miller BJ. Meta-analysis of Cerebrospinal Fluid Cytokine and Tryptophan Catabolite Alterations in Psychiatric Patients：Comparisons Between Schizophrenia，Bipolar Disorder，and Depression [J]. Schizophr Bull，2018，44（1）：75-83.
[8] Andreasen NC，Endicou J ，Spitizer RL，et al. The family history method using dignostic criteria：reliability and validity [J]. Arch Gen Psychiatry，1977，34（12）：1229.
[9] Adrian A，Elizabeth JC，Stephen CM，et al. The development of a questionnaire for use in epidemiological studies of depression in children and adolescents [J]. Int J Methods Psychiatr Res，1995，5（4）：237-249.
[10] Young RC，Biggs JT，Ziegler VE，et al. A rating scale for mania：reliability，validity and sensitivity [J]. Br J Psychiatry，1978，133：429-345.
[11] Alperson BL. The effect of semantic relatedness and practice on the color word test [J]. Dissertation Abstracts，1968， 28：3890.
[12] Berg EA. A simple objective technique for measuring flexibility in thinking [J]. J Gen Psychol，1948，39：15-22.
[13] Mi HA，Yu JE，Park YK. Association between Depression and hs-CRP Blood Levels in Korean Adults：Using the National Health and Nutrition Survey 2018 [J]. Korean Journal of Family Practice，2021，11（3）：191-196.
[14] Lamers F，Milaneschi Y，Smit JH，et al. Longitudinal Association Between Depression and Inflammatory Markers：Results From the Netherlands Study of Depression and Anxiety [J]. Biol Psychiatry，2019，85（10）：829-837.
[15] 陈建淮，姚志剑，赵可，等.单相和双相抑郁障碍患者脑白质网络全局效率与临床特征的相关分析[J].中华精神科杂志，2015，48（5）：271-278.
[16] de Azevedo-Marques Périco C，Duran FL，Zanetti MV，et al. A population-based morphometric MRI study in patients with first-episode psychotic bipolar disorder：comparison with geographically matched healthy controls and major depressive disorder subjects [J]. Bipolar Disord，2011，13（1）：28-40.
[17] 崔竹生，吴联霞，兰宾，等.抑郁障碍伴混合特征患者认知功能损伤特征研究[J].中国当代医药，2023，30（4）：94-97.
[18] 蔡溢，匡卫平，郭田生.单双相抑郁临床特征及认知功能比较[J].中南大学学报（医学版），2012，37（11）：1152- 1155.
[19] 聂纪伟，谭灵妍，赵永红，等.单双相抑郁患者早期临床特征及认知功能损害比较[J].心理月刊，2022，17（2）：114-116.
[20] 刘帅.伴和不伴自杀意念的青少年抑郁障碍患者脑结构及免疫炎症水平的差异研究[D].合肥：安徽医科大学，2021.
[21] 姚乾坤，康延海，周俊，等.青少年阈下抑郁患者血清HDAC3和BDNF检测在认知功能诊断中的临床价值[J].疑难病杂志，2023，22（5）：479-483.
[22] Colasanto M，Madigan S，Korczak DJ. Depression and inflammation among children and adolescents：A meta-analysis [J]. J Affect Disord，2020，277：940-948.
[23] Dantzer R，Wollman EE，Vitkovic L，et al. Cytokines，stress，and depression. Conclusions and perspectives [J]. Adv Exp Med Biol，1999，461：317-329.
[24] Pedrotti Moreira F，Wiener CD，Jansen K，et al. Childhood trauma and increased peripheral cytokines in young adults with major depressive：Population-based study [J]. J Neuroimmunol，2018，319：112-116.
[25] Miklowitz DJ，Portnoff LC，Armstrong CC，et al. Inflammatory cytokines and nuclear factor-kappa B activation in adolescents with bipolar and major depressive disorders [J]. Psychiatry Res，2016，241：315-322.
[26] 李一兰，李淑云，童梓顺，等.抑郁症治疗前后神经及认知执行功能的变化和相关性研究[J].中国医药科学，2021，11（18）：18-22.
[27] 左丹，杨锐，潘冰.分裂情感性精神病患者血清炎症因子和同型半胱氨酸水平与认知功能损害的相关性研究[J].全科医学临床与教育，2021，19（10）：903-906.
[28] 武红梅.精神分裂症患者炎症介质与认知功能障碍的相关性[J].医疗装备，2018，31（17）：66-67.
