噪声暴露与高血压发病风险的剂量-反应meta分析

doi:10.20047/j.issn1673-7210.2023.28.24

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Abstract Objective To investigate the dose-response relationship between noise exposure and the risk of hypertension. Methods Literatures on the dose-response relationship between noise exposure and hypertension published in CNKI, Wanfang Data, VIP, Chinese Biomedical Literature Service System, PubMed, EMBase, Web of Science, Cochrane Library were searched by computer. The search period was from inception to August 2022. Two researchers independently screened literatures, extracted data, and evaluated literatures quality. Stata 16.0 software was used for meta-analysis. Results A total of ten literatures were included, including 214 775 subjects. Meta-analysis showed that noise exposure increased the risk of hypertension (RR=1.31, 95%CI: 1.19-1.45, P＜0.001). The results of dose-response meta-analysis showed that there was a nonlinear relationship between noise exposure and hypertension (P＜0.05). Compared with 50 dB(A) noise exposure, 40 dB(A) noise exposure reduced the risk of hypertension by 3% (RR=0.97, 95%CI: 0.96-0.98, P＜0.001). 45 dB (A) noise exposure reduced the risk of hypertension by 1% (RR=0.99, 95%CI: 0.99-0.99, P＜0.001); 55 dB (A) noise exposure increased the risk of hypertension by 3% (RR=1.03, 95%CI: 1.03-1.04, P＜0.001); 60 dB (A) noise exposure increased the risk of hypertension by 4% (RR=1.04, 95%CI: 1.03-1.05, P＜0.001); 65 dB (A) noise exposure increased the risk of hypertension by 5% (RR=1.05, 95%CI: 1.03-1.06, P＜0.001); 70 dB (A) noise exposure increased the risk of hypertension by 5% (RR=1.05, 95%CI: 1.02-1.08, P＜0.001); 75 dB (A) noise exposure increased the risk of hypertension by 5% (RR=1.05, 95%CI: 0.99-1.11, P＜0.001); 80 dB (A) noise exposure increased the risk of hypertension by 6% (RR=1.06, 95%CI: 0.98-1.15, P＜0.001); 85 dB (A) noise exposure increased the risk of hypertension by 9% (RR=1.09, 95%CI: 1.00-1.18, P＜0.001); 90 dB (A) noise exposure increased the risk of hypertension by 17% (RR= 1.17, 95%CI: 1.09-1.26, P＜0.001); 95 dB (A) noise exposure increased the risk of hypertension by 31% (RR=1.31, 95%CI: 1.20-1.43, P＜0.001). The results of funnel plot showed that this study was less affected by publication bias and the results of meta-analysis were more reliable. Conclusion Noise exposure is associated with the risk of hypertension, and a large sample of high-quality literature needs to be included in future studies in order to provide a reliable reference for the prevention of hypertension.

Key words： Hypertension Noise Dose-response relationship Meta-analysis

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	HE Tiantian ZHANG Ye ZHAO Zhenxue ZHAO Chunshan

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HE Tiantian ZHANG Ye ZHAO Zhenxue ZHAO Chunshan. Meta-analysis of dose-response relationship of noise exposure and risk of hypertension[J]. 中国医药导报, 2023, 20(28): 110-114,154.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.28.24 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I28/110

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