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Meta-analysis of sperm count and morphological differences between overweight or obesity men and normal men |
GONG Zhizhong1 LI Haisong2 XUAN Zhihua3 DENG Sheng3 LIU Yifan4 WANG Xuyun4#br# |
1.Division of Medical Affairs, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
2.Department of Andrology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China;
3.Department of Andrology, Beijing Hospital of Traditional Chinese MedicineShunyi Hospital, Beijing 101399, China;
4.Department of Andrology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
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Abstract Objective To evaluate the sperm count and morphological differences between overweight or obesity men and normal men by meta-analysis. Methods The combined search was conducted with keywords such as overweight, obesity, sperm quantity, volume, and morphology, and the search time was set from January 2013 to December 2022 to collect studies on the influence of overweight or obesity on male sperm quantity and morphology by searching Wanfang Data, CNKI, and VIP. A meta-analysis of key data was performed by R 4.2.2 software. Results In this study, 12 literatures with a sample size of 4 299 were included. The results of meta-analysis showed that semen volume (MD=-0.25, 95%CI: -0.44 to -0.06, P=0.010), total sperm count (MD=-21.85, 95%CI: -39.44 to -4.26, P=0.015), normal sperm morphology rate (MD=-1.89, 95%CI: -3.48 to -0.30, P=0.020) of overweight group were lower than those of normal group. The semen volume (MD=-0.31, 95%CI: -0.55 to -0.07, P=0.010), total sperm count(MD=-37.82, 95%CI: -45.80 to -29.84, P< 0.001), sperm concentration (MD=-9.56, 95%CI: -16.03 to -3.10, P=0.004), and normal sperm morphology rate (MD=-2.10, 95%CI: -3.71 to -0.05, P=0.010) of obesity group were lower than those of normal group. The meta-analysis results were robust after the conversion of the effect model, and the Egger test results showed that there was no publication bias in the combined effect size (P>0.05). Conclusion Overweight or obesity men have abnormal sperm count and morphology compared to normal men.
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