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Research progress on the expression and prognostic value of microRNA-122 in perioperative period of primary liver cancer |
ZHANG Jialing1 LI Yuebing2 |
1.The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310053, China;
2.Department of Anesthesiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310005, China
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Abstract Primary liver cancer is one of the most common malignant tumors in clinic. It has the characteristics of poor prognosis and high mortality. With the deepening of research, many new techniques in clinic have been developed in the diagnosis and treatment of liver diseases. Among them, microRNA (miRNA) have become a new target for the treatment of liver diseases due to their high conservation, timing, stability, and tissue specificity. MiRNA-122 is a specific miRNA in liver tissue, which can inhibit the progression of primary liver cancer by regulating the expression of corresponding target molecules in liver cells. In recent years, studies on the value of miRNA-122 in primary liver cancer surgery have been carried out one after another, and they have shown certain advantages. Monitoring miRNA-122 during perioperative period of liver surgery is of great value for disease assessment and prognosis. This article reviews the expression and prognostic value of miRNA-122 in perioperative primary liver cancer.
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