慢性阻塞性肺疾病发生及治疗反应差异相关基因的研究进展

doi:10.20047/j.issn1673-7210.2023.28.10

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Abstract Chronic obstructive pulmonary disease (COPD) is a lung disease caused by a combination of genetic and environmental factors, and is characterized by irreversible airflow limitations. In recent years, new discoveries have been made in COPD genetics-related studies, such as the rs8004738 locus of serpin family A member 1, the rs1982073 locus of transforming growth factor β1, protein tyrosine phosphatase non-receptor type 6, telomerase reverse tranasecriptase gene, and matrix metalloproteinases have all been significantly associated with COPD; on this basis, several genes associated with differences in treatment response of COPD were also identified, such as potassium inwardly rectifying channel subfamily J member 2, nuclear receptor subfamily 3 group C member 1, and glucocorticoid inducible transcription factor 1. These newly identified genes and loci provide new insights into the pathogenesis of COPD, provide directions for finding new targets for the diagnosis and treatment of COPD, establish the basis for typing and prediction models for different phenotypes of COPD patients and promote the development of individualized therapy.

Key words： Chronic obstructive pulmonary disease Gene sequencing Susceptibility genes Differences in treatment response

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	DONG Han1 OU Jing1 ZHANG Cheng2 ZHANG Xiangyan2

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DONG Han1 OU Jing1 ZHANG Cheng2 ZHANG Xiangyan2. Research progress on genes related to occurrence and differences in treatment response of chronic obstructive pulmonary disease[J]. 中国医药导报, 2023, 20(28): 49-53.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.28.10 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I28/49

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