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| Research progress on the mechanism of ferroptosis and its application in myocardial ischemia-reperfusion injury |
| ZHOU Dongcheng1 YANG Yuhui1 HE Jianfeng1 XIA Zhengyuan2 |
1.The First Clinical Medical College, Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China;
2.Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China
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Abstract Ferroptosis is a new type of cell death discovered in recent years, which is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process. The factors that induce ferroptosis can directly or indirectly affect glutathione peroxidase through different pathways, leading to the decline of cellular antioxidant capacity and the accumulation of lipid reactive oxygen species, and ultimately lead to cellular oxidative death. Studies have shown that ferroptosis is closely related to pathophysiological processes of many diseases, such as tumors and ischemia-reperfusion injury. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. This article systematically summarizes the latest progress in the study of ferroptosis, providing reference for further understanding of its pathogenesis, and proposing new targets for treatment of related diseases.
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