|
|
|
| Analysis of the medication rules of Professor Yu Rui treated coronary heart disease combined with insomnia by harmonizing liver and heart based on the theory of double heart |
| LI Shuang1 YU Rui2 ZHANG Huan3 LIANG Jian3 YU You4 LI Keda5 ZHANG Jie6 HE Liangliang7 |
1.Graduate School, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110847, China;
2.Department of Science and Technology, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110847, China;
3.College of Nursing, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110847, China;
4.the Second Department of Cardiology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110021, China;
5.Institute of Traditional Chinese Medicine Standardization, Liaoning Academy of Traditional Chinese Medicine, Liaoning Province, Shenyang 110033, China; 6.Department of Traditional Chinese Medicine, the First Affiliated Hospital of China Medical University, Liaoning Province, Shenyang 110001, China; 7.Department of Emergency, Liaoning Provincial Armed Police Corps Hospital, Liaoning Province, Shenyang 110034, China
|
|
|
|
Abstract Objective To explore the medication rules of Professor Yu Rui treated coronary heart disease combined with insomnia by harmonizing liver and heart based on the theory of double heart. Methods The prescriptions of patients with coronary heart disease and insomnia treated by Professor Yu Rui in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine and Shenyang Tianren Heyi Intelligent Traditional Chinese Medicine (Internet) Hospital from August 2021 to February 2023 were collected. The traditional Chinese medicine inheritance computing platform V 3.0 was used to perform frequency, four nature, five flavours of drugs, meridian, association rules, and cluster analysis of the traditional Chinese medicine data to excavate the core prescriptions, and the rules of medication were explored. Results A total of 107 effective prescriptions were included, 197 Chinese medicine were used, and 11 Chinese medicine with frequency more than 40 were obtained, mainly for carminative formula, tranquillizing formula, and dissipating phlegm and eliminating blood stasis, etc. The four nature of drugs were mainly warm, cold, and calm drugs. The five flavours of drugs were bitter, sweet, and pungent. The main meridians were liver, spleen, lung, and heart meridians. There were 29 groups of common drug combinations, and 107 prescriptions could be divided into five clusters. Conclusion Professor Yu Rui treated coronary heart disease combined with insomnia with the method of harmonizing liver and heart based on the theory of double heart, and added or subtracted according to clinical syndrome differentiation.
|
|
|
|
|
|
[1] 中国心血管健康与疾病报告编写组.中国心血管健康与疾病报告2021概要[J].中国循环杂志，2022，37（6）：553-578.
[2] Zheng B，Yu C，Lv J，et al. Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults：A 10-year cohort [J]. Neurology，2019，93（23）：e2110-e2120.
[3] 雷晓庆，孙迪，王盼菲，等.冠心病患者睡眠质量与焦虑的相关性研究[J].中国慢性病预防与控制，2020，28（11）：870-873.
[4] Fr?覬jd LA，Munkhaugen J，Moum T，et al. Insomnia in patients with coronary heart disease：prevalence and correlates [J]. J Clin Sleep Med，2021，17（5）：931-938.
[5] 吴止境，陈晓虎.陈晓虎运用“双心同调”法治疗冠心病合并失眠之经验[J].江苏中医药，2022，54（6）：19-21.
[6] 中华医学会心血管病学分会介入心脏病学组，中华医学会心血管病学分会动脉粥样硬化与冠心病学组，中国医师协会心血管内科医师分会血栓防治专业委员会，等.稳定性冠心病诊断与治疗指南[J].中华心血管病杂志，2018，46（9）：680-694.
[7] 中华医学会神经病学分会睡眠障碍学组.中国成人失眠诊断与治疗指南[J].中华神经科杂志，2012，45（7）：534- 540.
[8] 国家药典委员会编.中华人民共和国药典[M].一部.北京：中国医药科技出版社，2020.
[9] 陈晓虎，朱贤慧，陈建东，等.双心疾病中西医结合诊治专家共识[J].中国全科医学，2017，20（14）：1659-1662.
[10] 张伟，陈蕊.基于“双心同调”理论自拟益气活血通脉方治疗气虚血瘀型稳定型心绞痛[J].中国临床研究，2022， 35（3）：372-376.
[11] 丁育钧，江玉文，蔡文玉，等.县域医共体早期双心模式干预老年高血压患者焦虑抑郁情绪的研究[J].中国医药科学，2023，13（5）：25-28，44.
[12] 张小燕.双心护理联合放松训练对慢性心力衰竭患者焦虑及抑郁影响的临床研究[J].中国当代医药，2022，29（5）：178-180，184.
[13] 郑洪新.中医基础理论专论[M].北京：中国中医药出版社.
[14] 冯嘉晨.和思想对中医学理论体系建构的模塑作用[D].南昌：江西中医药大学，2022.
[15] 于游，焦晓民，张欢，等.探“血中伏火”之理以“肝心和合”法治疗双心疾病[J].中华中医药杂志，2021，36（10）：5902-5905.
[16] 段盈竹，张欢，张颖，等.基于“和合”思想、运用“肝心和合”法治疗双心疾病[J].辽宁中医杂志，2022，49（2）：29- 32.
[17] 冯科冉，李伟霞，王晓艳，等.丹参化学成分、药理作用及其质量标志物（Q-Marker）的预测分析[J].中草药，2022，53（2）：609-618.
[18] 许小进，张一炎，张苏洁，等.复方丹参滴丸联合瑞舒伐他汀对急性心肌梗死经皮冠状动脉介入术后左心室重构及心肌纤维化的影响[J].中国医药导报，2019，16（35）：61-64.
[19] 钟树权.丹参川芎嗪治疗慢性心力衰竭的效果[J].中国当代医药，2021，28（23）：81-84.
[20] 刘珊，王文越，王永春，等.黄芪-当归药对益气活血作用的药效物质基础[J].中国实验方剂学杂志，2023，29（9）：28-36.
[21] 候雯，徐建.中药香附在人体不同生理系统中的药理作用研究进展[J].四川中医，2022，40（1）：213-216.
[22] 任伟光，郭丽丽，张翠英.川芎的研究进展及质量标志物（Q-marker）的预测分析[J].世界科学技术-中医药现代化，2021，23（9）：3307-3314.
[23] 程序，张利丹，谢雁鸣，等.丹参川芎嗪注射液治疗冠心病合并高血压病联合用药的复杂网络分析[J].中国药物警戒，2022，19（12）：1325-1331.
[24] 陈天阳，张萍，成扬.苍术酮含量测定方法、燥性及药理作用的研究进展[J].中成药，2022，44（6）：1902-1905.
[25] 吴永刚，蒋守涛，徐玉莲.加味栀子豉汤对冠状动脉粥样硬化性心绞痛失眠患者心肌保护作用和睡眠质量的影响[J].包头医学院学报，2020，36（7）：107-109.
[26] Zhu Z，Li J，Zhang X. Astragaloside Ⅳ Protects Against Oxidized Low-Density Lipoprotein（ox-LDL）-Induced Endothelial Cell Injury by Reducing Oxidative Stress and Inflammation [J]. Med Sci Monitor，2019，25：2132-2140.
[27] 杜澍金，张冬，张豪，等.黄芪甲苷基于血管内皮细胞间连接对脑缺血/再灌注大鼠脑保护作用[J].辽宁中医药大学学报，2021，23（4）：37-41.
[28] 张瀚文，于嘉祥，张伟，等.基于生信分析、分子对接技术研究越鞠丸改善动脉硬化的机制并虚拟筛选其特定活性成分[J].辽宁中医药大学学报，2022，24（6）：178-189.
[29] 张瀚文，于嘉祥，石岩，等.基于肝脏TMT标记定量蛋白质组学技术研究越鞠丸防治“双心疾病”的作用机制[J].中国实验方剂学杂志，2023，29（1）：26-36.
[30] 郭鹤，郑一，于嘉祥，等.基于网络药理学探讨活络效灵丹治疗冠心病的作用机制[J].辽宁中医杂志，2021，48（10）：143-149. |
|
|
|
