特应性皮炎患儿血清维生素D水平和补充维生素D疗效的系统评价

doi:10.20047/j.issn1673-7210.2023.27.24

Abstract
Figure/Table
References (28)
Related Citation (15)

Download: PDF (1387 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To determine serum 25-hydroxyvitamin D (25[OH]D) levels in children with atopic dermatitis (AD), and the effect of vitamin D supplementation on AD was evaluated by systematic analysis of vitamin D intervention. Methods The relevant literature on vitamin D and AD and vitamin D therapy for AD were searched by computer from PubMed, EMbase, CNKI, Wanfang Academic Journal Database, and VIP from January 2010 to November 2022. A meta-analysis method was used to systematically evaluate the retrieved literatures that met the inclusion criteria. Results Five randomized controlled trials (RCT) and 15 case-control studies were included. In RCT, eczema area and severity index in experimental group was higher than that in control group(WMD=-3.79, 95%CI[-6.38,-1.20], P=0.004); the scoring of atopic dermatitis in experimental group was higher than that in control group (WMD=-6.06, 95%CI[-10.12,-2.00], P=0.003). In the case- control study, serum 25(OH)D levels in AD children group were lower than that in control group (SMD=-0.80, 95%CI [-1.18,-0.41], P＜0.000 1). Conclusion Children with AD are at high risk of vitamin D deficiency, and vitamin D supplementation can improve clinical symptoms in children with AD.

Key words： Vitamin D Atopic dermatitis Systematic evaluation

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Xi1 WANG Jianing1 SUN Dan2 YAN Xiaoning2 LI Wenbin2

Cite this article:

CHEN Xi1 WANG Jianing1 SUN Dan2 YAN Xiaoning2 LI Wenbin2. Systematic evaluation of serum vitamin D levels and efficacy of vitamin D supplementation in children with atopic dermatitis[J]. 中国医药导报, 2023, 20(27): 108-112.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.27.24 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I27/108

[1] 毕志刚，田美华，林麟，等.湿疹与特应性皮炎皮损处细菌学研究[J].中华皮肤科杂志，2004，37（10）：595-597.
[2] 顾恒，尤立平，刘永生，等.我国10城市学龄前儿童特应性皮炎现况调查[J].中华皮肤科杂志，2004，37（1）：29-31.
[3] 顾洋，钱华.儿童特应性皮炎系统药物治疗研究进展[J].中国实用儿科杂志，2021，36（9）：655-660.
[4] 中华医学会皮肤性病学分会免疫学组，特应性皮炎协作研究中心.中国特应性皮炎诊疗指南（2020版）[J].中华皮肤科杂志，2020，53（2）：81-88.
[5] 中华医学会皮肤性病学分会儿童皮肤病学组.中国儿童特应性皮炎诊疗共识（2017版）[J].中华皮肤科杂志，2017，50（11）：784-789.
[6] 刘鹏月，杨帆，韩秀萍.特应性皮炎与维生D[J].中国麻风皮肤病杂志，2017，33（11）：693-697.
[7] 申春平，徐子刚.儿童特应性皮炎的诊断与非系统治疗进展[J].中国实用儿科杂志，2021，36（9）：649-655.
[8] Camargo CA，Ganmaa D，Sidbury R，et al. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children [J]. J Allergy Clin Immunol，2014，134（4）：831-835.
[9] Lara-Corrales I，Huang CM，Parkin PC，et al. Vitamin D Level and Supplementation in Pediatric Atopic Dermatitis：A Randomized Controlled Trial [J]. J Cutan Med Surg，2019，23（1）：44-49.
[10] Mansour NO，Mohamed AA，Hussein M，et al. The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis：A randomized controlled trial [J]. Pharmacol Res Perspect，2020，8（6）：e00679.
[11]向娟.VD辅助治疗儿童特应性皮炎的作用及其机制研究[D].重庆：重庆医科大学，2019.
[12] 朱林娜，张雁来，旁纯，等.血清维生素D水平对儿童特应性皮炎的影响[J].黑龙江医药科学，2018，41（1）：23-25.
[13] Xiang J，Wang H，Li T. Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Derma- titis in Children [J]. Dermatology，2019，235（3）：196-204.
[14] Di Filippo P，Scaparrotta A，Rapino D，et al. Vitamin D supplementation modulates the immune system and improves atopic dermatitis in children [J]. Int Arch Allergy Immunol，2015，166（2）：91-96.
[15] Cheon BR，Shin JE，Kim YJ，et al. Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels，and the severity of atopic dermatitis in children [J]. Korean J Pediatr，2015，58（3）：96-101.
[16] D’Auria E，Barberi S，Cerri A，et al. Vitamin D status and body mass index in children with atopic dermatitis：A pilot study in Italian children [J]. Immunol Lett，2017，181：31-35.
[17] Dogru M. Is vitamin D level associated with the natural course of atopic dermatitis?[J]. Allergol Immunopathol（Madr），2018，46（6）：546-551.
[18] Lipińska-Opa?覥ka A，Wawrzyniak A，Lewicki S，et al. Evaluation of Immune Indices and Serum Vitamin D Content in Children with Atopic Dermatitis [J]. Adv Exp Med Biol，2017，1020：81-89.
[19] Raj KP，Handa S，Narang T，et al. Correlation of serum vitamin D levels with severity of pediatric atopic dermatitis and the impact of vitamin D supplementation on treatment outcomes [J]. J Dermatolog Treat，2022，33（3）：1397-1400.
[20] Su O，Bahal?覦 AG，Demir AD，et al. The relationship between severity of disease and vitamin D levels in children with atopic dermatitis [J]. Postepy Dermatol Alergol，2017， 34（3）：224-227.
[21] Lee YW，Choon SE，Izham S. Serum 25-Hydroxyvitamin D deficiency in Malaysian children with severe atopic dermatitis [J]. Med J Malaysia，2019，74（4）：259-265.
[22] 付金玲，李其林，庞纯.儿童特应性皮炎患者血清维生素D、总IgE及嗜酸性粒细胞水平的相关性研究[J].皮肤性病诊疗学杂志，2021，28（5）：357-360.
[23] 张艳林，吴剑波.儿童特应性皮炎血清25-羟维生素D的表达及其临床意义[J].吉林医学，2020，41（10）：2318- 2320.
[24] 李敏，谢骏逸，杨潇，等.特应性皮炎患儿56例外周血25羟基维生素D的检测[J].中国皮肤性病学杂志，2016， 30（12）：1227-1229，1232.
[25] 邱萌，陆晓霏，马剑辉.特应性皮炎患儿血清25-羟维生素D3水平变化及其临床意义[J].山东医药，2017，57（44）：56-58.
[26] 陈泽璇，刘智.特应性皮炎患儿血清维生素D与病情的相关性研究[J].中国卫生标准管理，2021，12（10）：19-22.
[27] 唐满玲，顾敏，陈祥，等.特应性皮炎患儿临床特征及血清Apo A1、25（OH）D、EDN水平变化[J].中国医师杂志，2022，24（2）：256-259，265.
[28]刘琳.618例变态反应性皮肤病患者血清特异性IgE检测结果分析[J].实验与检验医学，2014，32（3）：322-324.