通州地区3~6岁儿童反复呼吸道感染病原菌分布及免疫监测结果分析

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Abstract Objective To analyze the pathogen distribution and immunological monitoring results of recurrent respiratory infection in 3-6 years old children in Tongzhou District. Methods A total of 135 children with recurrent respiratory infection admitted to Beijing Luhe Hospital, Capital Medical University ("our hospital" for short) from March 2015 to July 2017 were selected as the observation group, the samples of children′s secretions were extracted and pathogenic bacteria were cultured and identified, and the distribution of pathogenic bacteria was analyzed, another 87 healthy children carried physical examination in our hospital in the same period were selected as control group, the humoral immunity index, cellular immunity index and inflammatory cytokine level were compared between the two groups. Results Ninety-four pathogenic bacteria were detected in the observation group, Gram-positive bacteria accounted for 27.66%, Gram-negative bacteria accounted for 72.34%, detection rate of Gram-positive bacteria was significantly lower than that of Gram-negative bacteria(P < 0.01); there was no significant difference in immunoglobulin A (IgA) and C4 between the two groups (P > 0.05), the immunoglobulin M (IgM), immunoglobulin G (IgG) and C3 in observation group were significantly lower than those in control group (P < 0.01); there was no significant difference in CD4+ between the two groups (P > 0.05), the CD3+ and CD4+/CD8+ in observation group were significantly lower than those in control group, and the CD8+ was significantly higher than control group (P < 0.01); the interleukin-4 (IL-4), IL-6 and IL-10 in the observation group were significantly higher than those in the control group, the IL-12 was significantly lower than the control group (P < 0.01). Conclusion 3-6 years old children with recurrent respiratory tract infection have low immunologic function, Gram-negative bacteria are the main pathogens of infection, according to the detection results of pathogenic bacteria and immunologic function, appropriate antibiotics or immunologic enhancers should be selected to treat the children and improve their prognosis.

Key words： Recurrent respiratory infection Pathogenic bacteria Humoral immunity Cellular immunity Inflammatory cytokine

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	LIU Wei WU Hongbo

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LIU Wei WU Hongbo. Analysis on pathogen distribution and immunological monitoring results of recurrent respiratory infection in 3-6 years old children in Tongzhou District[J]. 中国医药导报, 2018, 15(32): 84-87.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I32/84

[1] 石正英，管建宏，施益农.儿童反复呼吸道感染72例致病因素分析[J].临床肺科杂志，2017，22（9）：1711-1713.
[2] Shima K，Coopmeiners J，Graspeuntner S，et al. Impact of micro-environmental changes on respiratory tract infections caused by intracellular bacteria [J]. FEBS Lett，2016， 590（21）：3887.
[3] 胡仪吉.反复呼吸道感染的诊断标准[J].中华儿科杂志，1988，26（1）：41.
[4] 王桂玲，王媛媛，杨征.江苏省宿迁市儿童反复呼吸道感染相关因素及治疗现状分析[J].中国医药，2015，10（6）：804-808.
[5] Shah S N，Ullah B，Basit A，et al. Prevalence and susceptibility patterns of bacteria causing respiratory tract infections in North Waziristan，Pakistan [J]. J Pharm Sci，2016， 29（2 Suppl）：701-706.
[6] 郝素莲.坝上3～6岁儿童反复上呼吸道感染的病因调查与分析[J].山西医药杂志，2015，44（13）：1483-1485.
[7] 薛继红.儿童下呼吸道感染病原菌分布及耐药性[J].中国微生态学杂志，2016，28（2）：192-194.
[8] 王贞，王斌，付琳，等.西安市儿童福利院小儿下呼吸道感染病原菌分析[J].河北医学，2016，22（4）：592-595.
[9] 黎明，江泓，谢雄，等.反复呼吸道感染患儿病原菌分布与耐药性分析[J].中华医院感染学杂志，2016，26（13）：3092-3094.
[10] 汪玲娟，王明欢，龚方彪，等.儿童呼吸道感染的病原菌分布与耐药性特点及血清相关免疫指标变化研究[J].中华医院感染学杂志，2018，28（6）：939-942.
[11] 朱琼，余莉，陈小利.小儿反复呼吸道感染与免疫水平及微量元素相关影响分析[J].贵州医药，2016，40（1）：32-33.
[12] 唐秀英，李莉，席向红，等.儿童反复呼吸道感染与免疫球蛋白及IgG亚类的相关性研究[J].中国儿童保健杂志，2016，24（8）：873-876.
[13] 金伟，吴红丽，栗雪英，等.小儿反复呼吸道感染与微量元素及免疫指标的相关性研究[J].山西医药杂志，2016， 45（17）：2033-2035.
[14] 马力忠，王桂兰，梁桂明，等.免疫调节剂对小儿反复呼吸道感染临床症状及免疫功能的影响[J].中国妇幼保健，2016，31（2）：414-415.
[15] 马亮，严良烽，曾慧，等.呼吸道感染患者病原性细菌的临床检验分析[J].中国现代医生，2017，55（30）：115-117.
[16] 林素挺，陈平，崔大伟.急性呼吸道感染门诊患者的临床特征和病毒谱分析[J].中国现代医生，2017，55（18）：116-119，122.
[17] 金玉晶，韩雪，葛国岚，等.穴位埋线疗法对反复呼吸道感染患儿免疫功能的影响[J].中医学报，2017，32（1）：22-25.
[18] 王萍，周戎，何永涛，等.反复呼吸道感染患儿血清免疫指标的观察分析[J].中华医院感染学杂志，2016，26（15）：3554-3556.
[19] 陈小燕，周卫萍.反复呼吸道感染患儿的病原菌分布与免疫功能监测[J].中华医院感染学杂志，2016，26（19）：4521-4523.
[20] 王雯君，颜云宙，袁芬芬，等.血清IL-6、IL-10、TNF-α及免疫蛋白动态监测在小儿肺部反复感染中的应用价值[J].中国妇幼保健，2017，32（12）：2634-2636.
[21] 菅敏，李俊新，刘超.T淋巴细胞亚群及微量元素与小儿反复呼吸道感染的关系[J].中国医学创新，2016，13（4）：61-64.
[22] 吴鸿波，刘伟，杨红秀，等.北京市通州地区小儿急性呼吸道感染病原学分析[J].中国医药导报，2018，15（5）：89-93.