德谷门冬双胰岛素联合利拉鲁肽强化治疗对超重/肥胖2型糖尿病患者的糖脂代谢及内脏脂肪指数的影响

doi:10.20047/j.issn1673-7210.2023.27.19

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Abstract Objective To investigate the effects of Insulin Degludec/Insulin Aspart and Liraglutide (IDAL) on glucose and lipid metabolism and visceral adiposity index in newly diagnosed overweight/obese patients with type 2 diabetes mellitus. Methods A total of 112 newly diagnosed overweight/obese type 2 diabetes mellitus patients who were treated in the Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University from May 2021 to June 2022 were divided into IDAL group and bolus-basal Insulin (BBI) group by random number table method, with 56 cases in each group. The two groups were intensive treated for eight weeks. The glucose and lipid metabolism indexes, insulin resistance related indexes, visceral adiposity index, the adverse reactions, and medication compliance were compared before and after treatment. Results After treatment, fasting blood glucose, 2 h postprandial blood glucose, glycated hemoglobin, fructosamine, triglyceride, total cholesterol, and low density lipoprotein cholesterol in both groups were lower than before treatment, while high density lipoprotein cholesterol was higher than before treatment, and triglyceride, total cholesterol and low density lipoprotein cholesterol in the IDAL group were lower than those in the BBI group, high density lipoprotein cholesterol was higher than that in BBI group (P＜0.05). After treatment, body mass index, waist circumference and visceral fat index in the IDAL group were lower than before treatment, and the IDAL group was lower than the BBI group (P＜0.05), and the steady-state model insulin resistance index in the two groups was lower than before treatment, and the IDAL group was lower than the BBI group (P＜0.05). The incidence of gastrointestinal adverse reaction in IDAL group was higher than that in BBI group, and the incidence of hypoglycemia in the IDAL group was lower than that in the BBI group, while the drug compliance was significantly higher (P＜0.05). Conclusion IDAL intensive therapy can effectively improve the glucose metabolism indexes of overweight/obese patients with type 2 diabetes, and has more advantages in the improvement of lipid metabolism indexes, insulin resistance and visceral adiposity index, and has a lower incidence of hypoglycemia and better medication compliance.

Key words： Insulin Degludec/insulin Aspart Liraglutide Type 2 diabetes mellitus Glucose and lipid metabolism Visceral adiposity index

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	HUANG Wensen1 LI Jingyun1 HONG Beverlysy2 KANG Jinfen1 HUANG Sijing1 CHEN Liyun1 CHEN Yun1

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HUANG Wensen1 LI Jingyun1 HONG Beverlysy2 KANG Jinfen1 HUANG Sijing1 CHEN Liyun1 CHEN Yun1. Effect of Insulin Degludec/Insulin Aspart combined with Liraglutide on glucose and lipid metabolism and visceral adiposity index in overweight/obese patients with type 2 diabetes mellitus[J]. 中国医药导报, 2023, 20(27): 86-89,94.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.27.19 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I27/86

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