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| Research progress of severe analgesia and sedation on brain protection in patients with neurological severe conditions |
| LU Ming1 ZHANG Xuezhi1 LUO Taotao1 XIE Yongle2 |
1.The First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Province, Lanzhou 730000, China;
2.Department of Intensive Care Medicine, the First People’s Hospital of Tianshui, Gansu Province, Tianshui 741000, China
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Abstract Traumatic brain injury (TBI) patients with pain, agitation and stress response lead to tachycardia, elevated blood pressure, and increased increased intracranial pressure, etc., increasing the risk of rebleeding, accidental injury, and death. Effective analgesia and sedation help control intracranial pressure and avoid violent fluctuations, especially during invasive procedures. Analgesic sedation can achieve brain protection. There is no definite plan of analgesia and sedation for patients with severe neurological diseases. How to rational analgesia and sedation is a problem faced by clinicians. This article reviewed the pathophysiological changes, the necessity of analgesia and sedation, the protective effects of commonly used analgesia and sedation drugs, and related debates, aiming to provide reference for the selection of analgesia and sedation programs for craniocerebral trauma.
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