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| Effect of Shenqi Tiaoti Decoction combined with Western medicine in the treatment of polycystic ovarian syndrome with spleen deficiency and phlegmatic hygrosis |
| DING Chunli1 XU Fang2 LI Yan3 HOU Lihui2▲ |
| 1.Gynecology of Chinese Medicine, the First Clinical School of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Haerbin 15004, China; 2.Department of Gynaecology, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Heilongjiang Province, Haerbin 150040, China; 3.Chinese Medicine Transformation Research Center, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Heilongjiang Province, Haerbin 150040, China |
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Abstract Objective To observe the clinical effect of Shenqi Tiaoti Decoction combined with Western medicine in the treatment of polycystic ovarian syndrome with spleen deficiency and phlegmatic hygrosis. Methods A total of 86 polycystic ovarian syndrome patients with spleen deficiency and phlegmatic hygrosis, who cured in Outpatient Service of Gynaecology Department in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from June 2014 to March 2017, were divided into control group and observation group according to registration order, with 43 cases in each group. The control group was given lifestyle intervention and drug therapy, while the observation group was given Shenqi Tiaoti Decoction on the base of control group. The TCM symptom score, serum hormone, insulin resistance and ovary indexes of two groups before and after treatment were recorded. And the total effective rates of two groups were calculated. Results After treatment, the symptom scores delayed menorrhea, nausea phlegm, mentally fatigued and tongue thick and greasy of two groups were all obviously lower than before, and those in observation group were all lower than control group, the differences were statistically significant (P < 0.05). After treatment, the testosterone, estradiol, luteinizing hormone, follicle stimulating hormone, fasting blood glucose, fasting insulin and insulin resistance index of two groups were all obviously lower than before, and those in observation group were all obviously lower than control group, the differences were statistically significant (P < 0.05). After treatment, the ovarian volume and number of basal sinus follicles of two groups were both obviously less than before, and the ovarian volume, number of basal sinus follicles in observation group were lower than control group, the mature follicles in observation group was more than control group, the differences were statistically significant (P < 0.05). The total effective rate of clinical treatment in observation group was obviously higher than control group, the difference was statistically significant (P < 0.05). Conclusion Shenqi Tiaoti Decoction combined with Western medicine has curative effect in the treatment of polycystic ovarian syndrome with spleen deficiency and phlegmatic hygrosis, it can effectively improve symptoms of spleen deficiency and phlegmatic hygrosis, and regulate endocrine disorders and blood sugar metabolism, promote the recovery of ovarian function.
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[1] 韦娟冰.来曲唑用于多囊卵巢综合征患者促排卵的临床疗效及安全性评价[J].中国临床药理学杂志，2015，31（19）：1928-1930.
[2] 姜朵生，张迎春，吴献群，等.针药联合克罗米芬治疗多囊卵巢综合征导致不孕症：随机对照研究[J].中国针灸，2015，35（2）：114-118.
[3] The Rotterdam ESHRE/ASRM2sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic crite ria and long2term health risks related to polycystic ovary syn2drome（PCOS） [J]. Hum Rep rod，2004， 19（1）：41-47.
[4] 梁茂新，高天舒.《中药新药临床研究指导原则》脏腑诸证考察与分析[J].中国中医基础医学杂志，2008，14（5）：330-331，342.
[5] 程雅洁，温建艳，田晓利，等.2型糖尿病合并抑郁患者炎性因子和胰岛素抵抗指数的变化及其临床意义[J].中国生化药物杂志，2017，37（6）：72-73.
[6] 黄晓花，韩毓，韦佩佳，等.不同腹腔镜剥离术式对子宫内膜异位症患者性激素、窦卵泡数及卵巢体积的影响[J].中国内镜杂志，2017，23（5）：74-78.
[7] 乐杰.妇产科学[M].7版.北京：人民卫生出版社，2008：315-317.
[8] 武红琴，阮祥燕，卢永军，等.多囊卵巢综合征患者合并代谢综合征的患病率和预测指标[J].首都医科大学学报，2015，10（4）：553-558.
[9] 秦静波，王济.多囊卵巢综合征中医体质类型及辨体论治思路[J].中医杂志，2016，57（18）：1553-1556.
[10] 汪梦洁，俞洁，黄娜，等.多囊卵巢综合征中医证素特点研究[J].云南中医学院学报，2017，40（5）：27-29，48.
[11] 周凌云，徐传花，李淑萍，等.针药结合治疗肥胖型多囊卵巢综合征脾虚痰湿证临床观察[J].上海针灸杂志，2016， 35（10）：1213-1215.
[12] 蒋英.益肾活血汤治疗肾虚血症型多囊卵巢综合征排卵障碍性不孕的效果[J].广东医学，2016，37（z1）：242-243.
[13] 罗梅，成臣，马小平，等."补肾活血散瘀汤"治疗卵巢型子宫内膜异位症30例临床观察[J].江苏中医药，2016， 48（1）：40-44.
[14] 王萍，邵渝，林辉，等.化痰调经方联合达英-35治疗多囊卵巢综合征痰湿阻滞证的临床研究[J].北京中医药大学学报，2017，40（1）：77-82.
[15] 李珊珊，孙印石.西洋参多糖结构与药理活性研究进展[J].特产研究，2017，39（3）：68-71.
[16] 赵彩霞，靳会欣.丹参多酚酸盐的药理作用机制及临床应用研究进展[J].河北医药，2017，39（2）：294-299.
[17] 王艳梅，曹俊岭.丹参中酚酸类化合物的化学和药理研究进展[J].世界中医药，2016，11（6）：1126-1130.
[18] 张酉珍，苏光悦，夏晓艳，等.天然达玛烷型皂苷降血糖作用的研究进展[J].中草药，2016，47（15）：2758-2763.
[19] 左军，张文钊，胡晓阳，等.黄芪现代药理及临床研究进展[J].中医药信息，2014，31（1）：111-112.
[20] 沙雯君，陆灏.黄芪调节糖尿病患者血糖稳态作用的研究进展[J].国际中医中药杂志，2015，4（1）：87-89.
[21] 曹玉梅，曹秀娟，黄瑞华，等.黄芪注射液联合阿托伐他汀治疗早期糖尿病肾病的临床效果[J].中国医药，2016，（4）：543-546. |
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