|
|
Professor Zhang Yu’s experience in treating nephrotic proteinuria based on “strengthening essence and reducing toxicity” |
ZHANG Qi ZHANG Yu |
Department of Nephropathy, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
|
|
|
Abstract Proteinuria is an important observation index for clinical treatment of chronic kidney disease patients. It can not only reflect kidney damage, but also has toxic effects on the kidney. It is the strongest predictor of end-stage kidney disease. Therefore, how to eliminate proteinuria is very important for patients with chronic kidney disease. Professor Zhang Yu believes that the production of proteinuria is based on the deficiency of spleen and kidney, the disadvantage of lung qi, and is also induced by the toxin of rheumatism and blood stasis. Therefore, this article explores and summarizes the six methods of tonifying the kidney and nourishing the yuan, strengthening the spleen and nourishing the earth, promoting lung and clearing diuresis, dispelling wind and detoxifying, resolving dampness and turbidity, and removing blood stasis and detoxifying from the perspective of “strengthening essence and reducing toxicity”. All methods should be carried out simultaneously and used alternately to achieve the goal of “strengthening the essence and supporting the root, eliminating pathogenic factors and preventing the change”, and provide a broader idea for clinical prescription of nephrotic proteinuria.
|
|
|
|
|
[1] 张琳,曹式丽.曹式丽从毒论治IgA肾病经验[J].辽宁中医杂志,2015,42(12):2315-2316.
[2] 李苹.从络论治慢性肾脏病的文献研究[D].济南:山东中医药大学,2014.
[3] 沈翀奇.补肾益精法治疗蛋白尿55例[J].中西医结合心血管病电子杂志,2019,7(32):159,161.
[4] 李博,耿刚.黄芪的化学成分与药理作用研究进展[J].中西医结合研究,2022,14(4):262-264.
[5] 马艳春,胡建辉,吴文轩,等.黄芪化学成分及药理作用研究进展[J].中医药学报,2022,50(4):92-95.
[6] 陈述枚.蛋白尿在肾小球疾病进展中的意义[J].中国实用儿科杂志,1999(8):6-7.
[7] 李刘生,张昱.黄芪治“肾”新论[J].世界中西医结合杂志,2017,12(11):1612-1615.
[8] 徐进,蒋春波.中药黄芪治肾病“机理”说[J].陕西中医药大学学报,2022,45(2):127-131.
[9] 于俊生,杜雅静,汪慧惠.蝉蜕、僵蚕对系膜增生性肾小球肾炎模型大鼠肾组织Toll样受体4表达的影响[J].中华中医药学刊,2015,33(1):7-9,1.
[10] 张燕伟.慢性持续期原发性IgA肾病血尿伴轻度蛋白尿患者中医证候、临床指标及肾脏病理分级研究[D].天津:天津中医药大学,2022.
[11] 余怡,张昱,张秋.张昱教授应用祛风法治疗肾病蛋白尿经验[J].世界中西医结合杂志,2021,16(3):441-445.
[12] 马思佳,张昱.张昱从风论治IgA肾病蛋白尿思路与方法[J].中医学报,2022,37(2):341-344.
[13] 王如梦,张昱.张昱教授运用药对治疗慢性肾炎经验总结[J].浙江中医药大学学报,2021,45(8):895-899.
[14] 孙文畅,杨隆河,邱彦,等.独活挥发油对N-脂肪酰基乙醇胺水解酶的抑制作用及抗炎作用研究[J].中国中药杂志,2011,36(22):3161-3166.
[15] 王俊南.芡实壳源柯里拉京对LPS诱导的RAW264.7细胞炎症反应影响研究[D].武汉:武汉轻工大学,2020.
[16] 刘琳,刘洋洋,占颖,等.芡实的化学成分、药理作用及临床应用研究进展[J].中华中医药杂志,2015,30(2):477-479.
[17] 周璐丽,曾建国.独活化学成分及药理活性研究进展[J].中国现代中药,2019,21(12):1739-1748.
[18] 叶敏.薏苡仁水提液对免疫抑制小鼠免疫功能的影响[J].安徽医药,2006,10(10):727-729.
[19] 付敬菊,董学,钟方晓,等.薏苡仁的营养组成与现代药理研究进展[J].粮油食品科技,2023,31(1):93-99.
[20] Chen H,Wang MC,Chen YY,et al. Alisol B23-acetate attenuates CKD progression by regulating the renin-angiotens in system and gut-kidney axis [J]. Ther Adv Chronic Dis,2020,11:2040622320920025.
[21] 冯占荣,马俊杰,张以来,等.益肾健脾化湿颗粒治疗代谢综合征微量白蛋白尿症40例临床观察[J].湖南中医杂志,2017,33(10):17-19.
[22] 张维君,韩东卫,李冀.泽泻的化学成分及药理作用研究进展[J].中医药学报,2021,49(12):98-102.
[23] 张丽敏,常美莹.张昱应用蝉苏地黄汤治疗IgA肾病蛋白尿的经验探析[J].世界中西医结合杂志,2020,15(6):1042-1045.
[24] 刘瑾,隋在云.水蛭微粉对实验性动脉粥样硬化兔血脂水平影响[J].辽宁中医药大学学报,2015,17(6):26-28. |
|
|
|