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| Correlation of retinal arteriolar-to-venular diameter ratio with the severity of hypertensive disorders of pregnancy and pregnancy outcome |
| ZHANG Yan ZHANG Jing XU Rui |
Department of Obstetrics and Gynecology, East District, Anhui Maternal and Child Health Hospital, Anhui Province, Hefei 230000, China
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Abstract Objective To investigate the correlation of retinal arteriolar-to-venular diameter ratios (AVR) with the severity of hypertensive disorders of pregnancy and pregnancy outcome. Methods A total of 150 patients with hypertensive disorders of pregnancy admitted to Anhui Maternal and Child Health Hospital, Anhui Province from January 2020 to January 2022 were selected as research object. According to the severity of disease, the patients were divided into gestational hypertension group (53 cases), mild preeclampsia group (50 cases), and severe preeclampsia group (47 cases); retinal AVR was compared among three groups, and the relationship between retinal AVR and the severity of hypertensive disorders of pregnancy was analyzed. According to the pregnancy outcome, the patients were divided into good pregnancy outcome group (118 cases) and bad pregnancy outcome group (32 cases); the influencing factors of adverse pregnancy outcomes in patients with hypertensive diseases of pregnancy was analyzed. Results Retinal AVR in severe preeclampsia group was lower than that in mild preeclampsia group and gestational hypertension group; retinal AVR in mild preeclampsia group was lower than that in gestational hypertension group, and the differences were statistically significant (P＜0.05). Retinal AVR was negatively correlated with the severity of hypertensive disorders of pregnancy(r=-0.783, P＜0.05). There were significant differences in 24 h urinary protein, neutrophil count, placental growth factor, and the proportion of retinal AVR＜2/3 between good pregnancy outcome group and bad pregnancy outcome group (P＜0.05). 24 h urinary protein (OR=1.046), neutrophil count (OR=1.473), and retinal AVR ＜2/3(OR=7.272) were the risk factors for bad pregnancy outcomes in hypertensive disorders of pregnancy (P＜0.05). Conclusion Retinal AVR is associated with the severity of hypertensive disorders of pregnancy and bad pregnancy outcomes.
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[1] 梁振昌，唐龙，林璇，等.血清Lp-PLA2、Hcy、mALB、NAG、 CysC联合检测在妊娠期高血压疾病早期肾脏损伤中的诊断价值[J].中国医药科学，2021，11（9）：163-166，178.
[2] 张春利，岳建宏.妊娠期高血压疾病患者血清低密度脂蛋白载脂蛋白E水平变化及意义[J].山西医药杂志，2021， 50（1）：40-41.
[3] 刘婷婷，王娟妮，吴晓玲，等.序贯性子宫动脉超声、光电容积脉搏波联合血清学指标检测对妊娠高血压、子痫前期的诊断价值研究[J].新疆医科大学学报，2019，42（11）：1423-1429.
[4] 王晓艳，李莲英.妊娠期高血压疾病与KIR、HLA-G的相关性研究[J].中国妇幼保健，2020，35（7）：1194-1197.
[5] 施旭婷，胥红斌.妊娠期高血压疾病对高龄初产妇母婴结局的影响[J].实用临床医药杂志，2020，24（15）：93-95.
[6] 陶春，陈先侠.胱抑素C、尿酸诊断妊娠期高血压疾病肾脏损伤的临床价值[J].中国医药科学，2022，12（8）：88-91.
[7] 陈艺中，罗红，袁昌亮，等.妊娠高血压视网膜病变影响因素分析及血管内皮功能检测的临床意义[J].现代生物医学进展，2020，20（2）：319-323.
[8] 冯雪，王海伟，李闻思，等.基于SD-OCT分析高血压类型与视网膜血管管径的关系[J].山东大学耳鼻喉眼学报，2020，34（4）：64-68.
[9] 中华医学会妇产科学分会妊娠期高血压疾病学组.妊娠期高血压疾病诊治指南（2020）[J].中华妇产科杂志，2020， 55（4）：227-238.
[10] 谢幸，苟文丽.妇产科学[M].8版.北京：人民卫生出版社，2013.
[11] 赖科峰，陈柳青，连炬飞，等.联合检测尿mALB、血清β2-MG和CysC对诊断妊娠期高血压疾病早期肾损伤的意义[J].检验医学与临床，2019，16（13）：1894-1896.
[12] 张林林，王文卿，吴元赭.肾功能指标水平变化与妊娠期高血压疾病的相关性[J].东南国防医药，2021，23（4）：359-362.
[13] 戴龙芳，祖恩慧.妊娠期高血压疾病与终末期肾病之间的关联[J].中国妇幼健康研究，2018，29（12）：1603-1607.
[14] Mori A，Sumida D，Kondo R，et al. Impairment of endothelium-dependent vasodilator function of retinal blood vessels in adult rats with a history of retinopathy of prematurity [J]. J Pharmacol Sci，2021，146（4）：233-243.
[15] 黄峰，朱鹏立，林帆，等.高血压人群视网膜血管定量参数的改变及其与血压的相关性[J].心血管康复医学杂志，2015，24（5）：480-484.
[16] 汤卫春，郁剑锋，刘曼华.妊娠中晚期心理健康与孕妇视网膜血管管径变化的初步研究[J].世界临床药物，2015，36（9）：623-627，630.
[17] 耿韶辉，王雅丛，李艳涛，等.妊娠期高血压合并视网膜脱离临床特征的单中心研究[J].河北医药，2018，40（9）：1352-1354，1358.
[18] 王莹，黄晓波，鲁晓燕，等.分析妊娠期高血压疾病患者视网膜病变与其分类及围生儿预后的关系[J].航空航天医学杂志，2018，29（9）：1078-1079.
[19] 程科云，柴东剑，王娇，等.SD-OCT测量视网膜血管管径改变在预测高血压病患者靶器官损伤中的价值[J].浙江医学，2022，44（5）：526-529.
[20] 谭毅，周正银，农乐关，等.NLR、sFlt-1/PLGF对妊娠高血压疾病严重程度及妊娠不良结局的影响研究[J].广西医科大学学报，2021，38（2）：332-337.
[21] Streese L，Gander J，Carrard J，et al. Hypertension and retinal microvascular dysfunction（hypervasc）：protocol of a randomised controlled exercise trial in patients with hypertension [J]. BMJ Open，2022，12（6）：58997.
[22] Schreiberová Z，Chrapek O，■imi■ák J. Ocular complications of diabetes mellitus in pregnancy-case report [J]. Cesk Slov Oftalmol，2020，76（4）：166-170.
[23] Sharifizad M，Schmidl D，Werkmeister RM，et al. Retinal ve- ssel diameters，flicker-induced retinal vasodilation and retinal oxygen saturation in high- and low-risk pregnancy [J]. Acta Ophthalmol，2021，99（6）：628-636.
[24] 赵小艳，曹松梅，夏青，等.多学科联合模式对妊娠期高血压孕妇的管理效果研究[J].重庆医学，2020，49（21）：3601-3604，3608.
[25] 侯秀真，马合红，王佩，等.运动、饮食综合干预对妊娠期糖尿病合并妊娠期高血压孕妇影响观察[J].现代预防医学，2020，47（5）：848-851，887. |
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