恶性肿瘤患者衰弱综合征风险评估模型的构建与评价

doi:10.20047/j.issn1673-7210.2023.24.14

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Abstract Objective To investigate the related factors of asthenic syndrome in patients with malignant tumors, and construct a risk assessment model to predict its efficacy. Methods A total of 327 patients with malignant tumors who were hospitalized in the oncology department of a top-three hospital in Guangxi from May to August 2020 were selected. General data and laboratory indicators of the patients were collected, and grip strength was measured. The risk assessment model was determined by binary logistic regression analysis, and the model effect was tested by subject working characteristic curve. Results The incidence of asthenic syndrome in malignant tumor patients was 28.4%. There were significant differences in gender, age, grip strength, arm circumference, calf circumference, body mass index, erythrocyte, hemoglobin, total protein, albumin and prealbumin between the two groups (P＜0.05). Logistic regression results showed that gender, grip strength, arm circumference and albumin were the influencing factors of asthenic syndrome in malignant tumor patients (OR＜1, P＜0.05). H-L goodness of fit test was used to test the FMS risk prediction model (P＞0.05), and the model fit was good. When the area under ROC curve was 0.852 (95%CI: 0.807-0.897, P＜0.05), the sensitivity was 0.849, and the specificity was 0.722, the Youden index was the largest (0.572), and the prediction model score was 149 points. Conclusion The incidence of asthenic syndrome is high in patients with malignant tumors, and female patients and lower arm circumference, grip strength and albumin are risk factors for asthenic syndrome in patients with malignant tumors. 149 points is the optimal threshold value for the asthenic syndrome risk assessment model in patients with malignant tumors. The constructed asthenic syndrome risk assessment model has good diagnostic efficacy and can be verified in the next large sample.

Key words： Malignant tumor Asthenic syndrome Model

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	WEI Jiejing1*　LU Ting2*　YING Yanping3　HUANG Biaojin3　XU Yi4

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WEI Jiejing1*　LU Ting2*　YING Yanping3　HUANG Biaojin3　XU Yi4. Construction and evaluation of a risk assessment model for asthenic syndrome in patients with malignant tumors[J]. 中国医药导报, 2023, 20(24): 59-63.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.24.14 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I24/59

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