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| Study progress of graphene family nanomaterials for medical and pharmic properties with their effects on proliferation and osteogenic differentiation of mesenchymal stem cell |
| WEI Ziyuan ZHANG Xiaodong HE Jun LIU Danyang WANG Yang SHEN Lei |
Basic Medical Research Center, Qiqihar Medicine University, Heilongjiang Province, Qiqihar 161006, China
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Abstract In clinical, bone injury repair is a common problem, and bone tissue engineering can help overcome this problem. Graphene family nanomaterials possess potential values of inhibiting bacteria, countering inflammation and serving as bioscaffold etc. in bone tissue engineering. Although graphene family nanomaterials combined with mesenchymal stem cell can contribute to repair bone injury, they have intricate influence on proliferation and osteogenic differentiation of mesenchymal stem cell, the mechanism of which is not clear. To give full play to the application of graphene family nanomaterials in bone tissue engineering and avoid adverse reaction, in this paper, the medical and pharmic properties of graphene family nanomaterials are comprehensively analyzed, as well as the effect of them on the proliferation and osteogenic differentiation of mesenchymal stem cell and molecular mechanisms of the effects are explored in the hope of enhancing the research and application of graphene family nanomaterials in bone tissue engineering.
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