老年脓毒症患者血清SDC-1、CitH3水平表达及临床意义

doi:10.20047/j.issn1673-7210.2023.22.20

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Abstract Objective To investigate the expression and clinical significance of serum syndecan-1 (SDC-1) and citrullinated histone H3 (CitH3) in elderly patients with sepsis. Methods A total of 125 elderly patients with sepsis admitted to Fukuang General Hospital of Liaoning Health Industry Group (“our hospital” for short) from August 2017 to September 2022 were selected as the sepsis group. According to the severity of the condition, they were divided into general sepsis group (51 cases) and septic shock group (74 cases). According to the 28 day prognosis, they were divided into death group and survival group. In addition, 50 healthy individuals who underwent physical examination in our hospital during the same period were selected as the control group. The serum levels of SDC-1 and CitH3 were measured; multivariate logistic regression was used to analyze the influencing factors of poor prognosis in elderly patients with sepsis, and receiver operating characteristic curve (ROC) curve analysis was used to analyze the predictive value of serum SDC-1 and CitH3 for poor prognosis in elderly patients with sepsis. Results The levels of serum SDC-1 and CitH3 in the sepsis group were higher than those in the control group (P＜0.05). The levels of serum SDC-1 and CitH3 in septic shock group were higher than those in general sepsis group (P＜0.05). The levels of serum SDC-1 and CitH3 in the death group were higher than those in the survival group (P＜0.05). Increasing age, septic shock, organ injuries≥3 concurrent, prolonged anti infection initiation time, increased sepsis-related organ failure assessment scores, elevated SDC-1, and elevated CitH3 were independent risk factors for poor prognosis in elderly patients with sepsis (P＜0.05). The ROC curve analysis showed that the area under the curve of SDC-1 combined with CitH3 in predicting poor prognosis in elderly sepsis patients was larger than that of SDC-1 and CitH3 alone (P＜0.05). There was no difference between the SOFA score and the area under the curve of SDC-1 combined with CitH3 in predicting poor prognosis in elderly sepsis patients (P＞0.05). Conclusion The levels of serum SDC-1 and CitH3 in elderly patients with sepsis are elevated, and the combined detection of the two can be used as predictor of poor prognosis in elderly patients with sepsis.

Key words： Elderly Sepsis Syndecan-1 Citrullinated histone H3 Prognosis

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	LI Cong1 LI Lili1 LIU Hui2

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LI Cong1 LI Lili1 LIU Hui2. Expression and clinical significance of serum SDC-1 and CitH3 levels in elderly patients with sepsis[J]. 中国医药导报, 2023, 20(22): 92-96.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.22.20 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I22/92

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