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| Research progress of local antimicrobial peptides preparation for chronic wound treatment |
| XIANG Yang1 JIANG Zhuang2 ZHI Xiaosong2 WANG Huasong2 |
1.Graduate School, Wuhan University of Science and Technology, Hubei Province, Wuhan 430065, China;
2.Department of Orthopedics, General Hospital of Central Theater Command of Chinese People’s Liberation Army， Hubei Province, Wuhan 430070, China
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Abstract Antimicrobial peptides (AMPs) have good antibacterial properties and promote wound healing, and are potential substitutes for traditional antibiotics. However, AMPs is sensitive to the external environment and has a short action time, which is limited in local applications. The novel local AMPs preparation formed by carrier delivery or change of dosage form can achieve the purpose of slow release of AMPs, enhance the stability of AMPs and optimize the biological efficiency, and show important advantages in the clinical application of chronic wounds. To date, a variety of AMPs preparation have been developed in the form of nanoparticles, hydrogels, nanoparticle supported hydrogels, and self-assembling peptides, etc. In this paper, the general situation, antibacterial activity, and wound healing promoting properties of AMPs, preparation type of local AMPs preparations currently developed, and efficacy influencing factors are reviewed. The future development prospect of AMPs is discussed.
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