化疗引起骨髓抑制的机制及中医药防治的研究进展

doi:10.20047/j.issn1673-7210.2023.22.10

Abstract
Figure/Table
References (31)
Related Citation (15)

Download: PDF (588 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Myelosuppression is a common complication during chemotherapy. Patients may have immunosuppression, anemia, bleeding, and other clinical manifestations. In severe cases, patients cannot complete sufficient and full chemotherapy. The mechanism of myelosuppression mainly includes two aspects: on the one hand, chemotherapy affects the hematopoietic function of bone marrow by inducing the aging of hematopoietic stem cells and apoptosis of hematopoietic progenitors; on the other hand, chemotherapy can also destroy the hematopoietic ecological niche by inducing abnormal osteogenic-dipogenic differentiation of bone marrow, leading to abnormal signal pathways, disorder of hematopoietic growth factors, and affecting the hematopoietic microenvironment. In the treatment of myelosuppression, traditional medicine has gained clinical attention by virtue of its multiple targets, small side effects, low cost, and other advantages. Relevant clinical research and basic animal research are ongoing and have made some progress. Therefore, this article mainly reviews the mechanism of myelosuppression caused by chemotherapy and related research progress of traditional Chinese medicine prevention and treatment, providing reference for clinical chemotherapy drug selection and prevention and treatment of myelosuppression.

Key words： Chemotherapy Myelosuppression Related mechanism Hematopoietic cell Hematopoietic microenvironment

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YU Jiaojiao WANG Jie CHEN Chao

Cite this article:

YU Jiaojiao WANG Jie CHEN Chao. Research progress on mechanism of chemotherapy induced myelosuppression and its prevention and treatment with traditional Chinese medicine[J]. 中国医药导报, 2023, 20(22): 47-50.

URL:

https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.22.10 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I22/47

[1] Sung H，Ferlay J，Siegel RL，et al. Global Cancer Statistics 2020：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin，2021，71（3）：209-249.
[2] He K，Liu X，Hoffman RD，et al. G-CSF/GM-CSF-induced hematopoietic dysregulation in the progression of solid tumors [J]. FEBS Open Bio，2022，12（7）：1268-1285.
[3] 闫韶花.补肾健脾法防治结直肠癌辅助化疗所致骨髓抑制的疗效及机制探索[M].北京：中国中医科学院，2021：204.
[4] Liu JY，Souroullas GP，Diekman BO，et al. Cells exhibiting strong p16（INK4a） promoter activation in vivo display features of senescence [J]. Proc Natl Acad Sci USA，2019，116（7）：2603-2611.
[5] Yamashita M，Passegué E， TNF-alpha coordinates hematopo- ietic stem cell survival and myeloid regeneration [J]. Cell Stem Cell，2019，25（3）：357.e7-372.e7.
[6] Herranz N，Gil J. Mechanisms and functions of cellular senescence [J]. J Clin Invest，2018，128（4）：1238-1246.
[7] Vogler M，Walter HS，Dyer MJS. Targeting anti-apoptotic BCL2 family proteins in haematological malignancies from pathogenesis to treatment [J]. Br J Haematol，2017，178（3）：364-379.
[8] 曾妙，黄洋，甘家丽，等.基于造血干细胞衰老及造血微环境损伤探讨骨髓抑制机制的研究进展[J].现代肿瘤医学，2020，28（22）：3990-3994.
[9] Zhou BO，Yu H，Yue R，et al. Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF [J]. Nat Cell Biol，2017，19（8）：891-903.
[10] 徐正阳，柴烁，张小晴，等.化疗抑制下骨髓BMP4对造血干/祖细胞周期、凋亡的调控及其机制[J].中国实验血液学杂志，2019，27（4）：1265-1271.
[11] 杨小萍，郑波.血管外膜细胞生物学特性及对造血干/祖细胞的支持作用[J].中国组织工程研究，2019，23（29）：4728-4734.
[12] Ding L，Saunders TL，Enikolopov G，et al. Endothelial and perivascular cells maintain haematopoietic stem cells [J]. Nature，2012，481（7382）：457-462.
[13] 杨闪闪，赵夙雅，陈冬梅，等.化疗后骨髓抑制的辨治思路及用药经验探析[J].中华中医药杂志，2022，37（12）：7162-7165.
[14] 方旭鹏，方丹，王薇，等.中医药治疗恶性肿瘤化疗后白细胞降低的研究进展[J].世界科学技术-中医药现代化，2022，24（7）：2539-2544.
[15] Wu J，Zhang W，Ran Q，et al. The differentiation balance of bone marrow mesenchymal stem cells is crucial to hematopoiesis [J]. Stem Cells Int，2018，2018：1540148.
[16] Li N，Hua J. Interactions between mesenchymal stem cells and the immune system [J]. Cell Mol Life Sc，2017，74（13）： 2345-2360.
[17] Ghode SS，Bajaj MS，Kulkarni RS，et al. Neuropilin-1 is an important niche component and exerts context-dependent effects on hematopoietic stem cells [J]. Stem Cells Dev，2017，26（1）：35-48.
[18] 汪变红，张明智，付晓瑞，等.化放疗骨髓抑制机制及防治研究进展[J].肿瘤基础与临床，2013，26（2）：162-165.
[19] Wei Q，Frenette PS. Niches for hematopoietic stem cells and their progeny [J]. Immunity，2018， 48（4）：632-648.
[20] Weiss J，Goldschmidt J，Andric Z，et al. Effects of trilaciclib on chemotherapy-induced myelosuppression and patient-reported outcomes in patients with extensive-stage small cell lung cancer：pooled results from three phase Ⅱ randomized，double-blind，placebo-controlled studies [J]. Clin Lung Cancer，2021，22（5）：449-460.
[21] 熊宏泰，高劲，于惠博，等.近20年中医药防治化疗后骨髓抑制研究现状可视化分析[J].中国中医药信息杂志，2023，30（3）：31-37.
[22] 祝微，王文娟，周杰，等.中医药防治肿瘤放化疗后骨髓抑制的用药规律分析[J].环球中医药，2020，13（1）：40-47.
[23] Wei Q，Zhang J，Hong G，et al. Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway [J]. Biomed Pharmacother，2016，84：931-939.
[24] Wang J，Ying YY，Chen ZH，et al. Guilu Erxian Glue inhibits chemotherapy-induced bone marrow hematopoietic stem cell senescence in mice may via p16INK4a-Rb signaling pathway [J]. Chin J Integrat Med，2020，26（11）：819- 824.
[25] Han J，Dai M，Zhao Y，et al. Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis [J]. J Ginseng Res，2020， 44（2）：291-299.
[26] Kang M，Park S，Chung Y，et al. Hematopoietic effects of angelica gigas nakai extract on cyclophosphamide-induced myelosuppression [J]. Plants（Basel），2022，11（24）：3476.
[27] 陈红宇，陈文莉，畅立圣，等.黄芪注射液穴位注射治疗化疗后白细胞减少症的临床研究[J].上海中医药杂志，2020，54（S1）：22-24.
[28] Zhang S，Mi Y，Ye T，et al. Carbohydrates and ginsenosides in shenmai injection jointly improve hematopoietic function during chemotherapy-induced myelosuppression in mice [J]. Chin Med，2022，17（21）：124.
[29] Mizuno S，Iino T，Ozawa H，et al. Notch1 expression is regulated at the post-transcriptional level by the 3’ untranslated region in hematopoietic stem cell development [J]. Int J Hematol，2018，107（3）：311-319.
[30] Bao W，Zhang Q，Zheng H，et al. Radix Astragali polysaccharide RAP directly protects hematopoietic stem cells from chemotherapy-induced myelosuppression by increasing FOS expression [J]. Int J Biol Macromol，2021，183：1715- 1722.
[31] 王云龙，安仕刚，曾强武，等.补肾调肝化瘀法防治化疗后骨髓抑制的实验研究[J].中国中医药现代远程教育，2020，18（24）：122-125.