老鹳草素抗骨质疏松症机制的研究进展

doi:10.20047/j.issn1673-7210.2023.22.09

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Abstract The ability of geraniin (Ge) to inhibit the proliferation and differentiation of osteoclasts (OC) and promote the proliferation and differentiation of osteoblasts (OB)， promotes bone marrow mesenchymal stem cells towards osteogenic differentiation. This paper reviews the literature and studies on Ge for osteoporosis by searching the databases of Vipshop, CNKI, and PubMed in recent years, and reviews the literature on the relevant cellular and signaling pathways involved in Ge, the mechanism of action of Ge against osteoporosis is found to promote proliferation and differentiation of OB mainly through upregulation of Wnt/β-catenin and expression of osteogenic transcription factor 2; inhibition of RANKL-induced nuclear factor-κB expression to exert inhibitory effects on OC differentiation. This paper further explores the mechanism of action of Ge against osteoporosis through a review, which provides new options and basis for the treatment of osteoporosis and research of new drugs.

Key words： Geraniin Osteoporosis Signal channel Cells Action mechanism

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	RUI Chen1 ZHAO Yifan1 LIU Tianpeng1 ZHAO Shaochuan1 GUO Yawen1 YANG Feng2

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RUI Chen1 ZHAO Yifan1 LIU Tianpeng1 ZHAO Shaochuan1 GUO Yawen1 YANG Feng2. Research progress on the mechanism of geraniin against osteoporosis[J]. 中国医药导报, 2023, 20(22): 43-46,59.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.22.09 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I22/43

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