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| Mechanism of iron accumulation and its research progress in neurodegenerative diseases |
| LIU Jiaoru1* YANG Hui2* WANG Haiyan2 XING Yonghua2 TONG Li1 SU Zhanhai2 WU Qiong1 |
1.Medical Institute of Qinghai University, Qinghai Provincial Key Laboratory of Traditional Chinese Medicine Research for Glucolipid Metabolic Diseases, Qinghai Province, Xining 810016, China;
2.Medical Institute of Qinghai University, Laboratory of Basic and Applied Research on Qinghai-Tibet Plateau Traditional Chinese Medicine Anti-tumor Medicine, Qinghai Province, Xining 810016, China
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Abstract The iron-dependent accumulation associated with lipid peroxides in cells, mitochondrial atrophy, and increased mitochondrial membrane density are the main pathological features of ferroptosis. It is different from the cell necrosis, autophagy, and apoptosis. The mechanism of ferroptosis usually involved with the accumulation of lipids and lipid peroxides, the imbalance of amino acid antioxidant system, and the disorder of iron metabolism. Therefore, ferroptosis is considered as a novel programmed cell death process. The signaling of mevalonic acid, transsulfur, and heat shock protein may play important roles in the ferroptosis process. Existing studies have shown that ferroptosis is strongly associated with the development of some neurodegenerative diseases. But the exact mechanism of this form of cell death has not been fully explored. This review summarizes the latest research development of the role of ferroptosis in neurodegenerative system diseases, and further understanding of ferroptosis may inform future clinical treatment research of neurodegenerative diseases.
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