3.0T磁共振钆塞酸二钠增强扫描对肝硬化患者肝脏再生结节良恶性质的鉴别诊断价值

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Abstract Objective To investigate the differential diagnostic value of gadoxetic acid disodium (Gd-EOB-DTPA) enhanced MRI for hepatic nodules in patients with liver cirrhosis. Methods From February 2015 to February 2017, in Hainan General Hospital, 43 patients with liver cirrhosis were selected, and they were given Gd-EOB-DTPA enhanced 3.0T dynamic MRI and conventional Gd-DTPA enhancement. The characteristics of the images in various phases were analyzed, the results of surgical specimen pathology were as gold standard, the test sensitivity and specificity of Gd-EOB-DTPA were evaluated. Results Gd-EOB-DTPA enhanced 3.0T MRI imaging could detected malignant nodules in the liver- specific stage, which were not found by conventional Gd-DTPA enhancement imaging. Compared with conventional Gd-DTPA enhancement, Gd-EOB-DTPA enhanced MRI detected more malignant nodules and it was not better than Gd-DTPA enhancement in detecting benign nodules. During the Gd-EOB-DTPA enhanced liver-gladder phase, most lesions appeared low signal intensity, and others appeared equal or high signal intensity (P < 0.01). Gd-EOB-DTPA enhanced MRI was better than Gd-DTPA enhancement in detecting malignant nodules (P < 0.01). The specificity of Gd-EOB-DTPA enhanced MRI was 100.00%, and the sensitivity was 93.18%. Conclusion Gd-EOB-DTPA enhanced MRI has high sensitivity and speeificity for the diagnosis of benign and malignant of liver′s abnormal perfusion nodules, and has differential diagnostic value.

Key words： Gadoxetic Acid Disodium MRI Liver cirrhosis Liver nodules Hepatocellular carcinoma

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	DONG Liwei WANG Fei LUO Shishi ZHAO Yingman CHEN Feng LI Jianjun

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DONG Liwei WANG Fei LUO Shishi ZHAO Yingman CHEN Feng LI Jianjun. Differential diagnostic value of gadoxetic acid disodium enhanced 3.0T MRI for hepatic nodules in patients with liver cirrhosis[J]. 中国医药导报, 2018, 15(31): 127-130.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I31/127

[1] Roberts LR，Sirlin CB，Zaiem F，et al. Imaging for the diagnosis of hepatocellular carcinnoma：A systematic review and meta-analysis [J]. Hepatology，2018，67（1）：401-421.
[2] Aube C，Bazeries P，Lebigot J，et al. Liver fibrosis，cirrhosis and cirrhosis-related nodules：imaging diagnosis and surveillance [J]. Diagn Interv Imaging，2017，98（6）：455-468.
[3] Matsumoto N，Ogawa M，Takayasu K，et al. Quantitative sonographic image analysis for hepatic nodules：a pilot study [J]. J Med Ultralsonics，2015，42（4）：505-512.
[4] Kim BR，Lee JM，Yoon JH，et al. Diagnostic performance of gadoxetic acid-enhanced liver MR imaging versus multidetector CT in the detection of dysplastic nodules and early hepatocellular carcinoma [J]. Radiology，2017，285（1）：134-146.
[5] Mortelé KJ，Praet M，Van VH，et al. CT and MR imaging findings in focal nodular hyperplasia of the liver：radiologic-pathologic correlation [J]. Am J Roe Ntgenol，2000，175（3）：687-692.
[6] Bioulac-Sage P，Balabaud C，Wanless IR：Diagnosis off ocal nodular hyperpla sia：not so easy [J]. Am J Surg Pathol，2001，25：1322-1325.
[7] Zhang TD，Zhu FP，Xu X，et al. Liver imaging reporting and data system：substantial discordance between CT and MR for imaging classification of hepatic nodules [J]. Acad Radiol，2016，23（3）：344-352.
[8] Wang YC，Chou CT，Lin CP，et al. The value of Gd-EOB-DTPA-enhanced MR imaging in characterizing cirrhosis nodules with atypical enhancement on Gd-DTPA-enhanced MR images [J]. PLoS One，2017，12（3）：e0174594.
[9] 黄利利，李梅.普美显在肝脏疾病诊断中的应用现状[J].中国普通外科杂志，2013，22（7）：938-943.
[10] Affo S，Yu LX，Schwabe RF. The role of cancer-associated fibroblasts and fibrosis in liver cancer [J]. Ann Rev Pathol，2017，24（12）：153-186.
[11] Diaz-Gonzalez A，Forner A. Surveillance for hepatocellular carcinoma. Best practice & research [J]. Clin Gastroenterol，2016，30（6）：1001-1010.
[12] 丁莺，曾蒙苏.普美显在肝硬化结节多步癌变及肝细胞癌早期诊断中的应用[J].临床肝胆病杂志，2013，29（10）：736-739.
[13] Huppertz A，Balzer T，Blakeborough A，et al. Improved detection of focal liver lesions at MR imaging： multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings [J]. Radiology，2004，230（1）：266-275.
[14] Ahn SS，Kim MJ，Lim JS，et al. Added value of gadoxetic acidenhanced hepatobiliary phase MR imaging in the diagnosis ofhepatocellular carcinoma [J]. Radiology，2010， 255（2）：459-466.
[15] Reimer P，Rummeny EJ，Shamsi K，et al. Phase Ⅱ clinical evaluation of Gd-EOB-DTPA：dose，safety aspects，and pulse sequence [J]. Radiology，1996，199（1）：177-183.
[16] Hamm B，Staks T，Mühler A，et al. Phase Ⅰ clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent：safety，pharmacokinetics，and MR imaging [J]. Radiology，1995，195（3）：785-792.
[17] 赵爽，李彩英，高凤霄，等.3.0T磁共振波谱及扩散加权成像联合应用对肝硬化的诊断价值[J].临床放射学杂志，2013，32（3）：344-347.
[18] 梁亮，陈财忠，饶圣祥，等.肝胆特异性磁共振对比剂Gd-EOB-DTPA在肝脏局灶性病变诊断中的应用研究[J].放射学实践，2012，27（7）：765-770.
[19] 邓娟.MRI钆塞酸二钠注射液（普美显）增强对肝脏结节的诊断价值[J].中外医学研究，2015，13（36）：60-61.
[20] 孙玉，张楠，侯洁，等.钆塞酸二钠MRI对肝细胞癌的诊断价值[J].临床肝胆病杂志，2018，34（1）：129-132.
[21] 王荃荣子，刘希胜，俞同福，等.Gd-EOB-DTPA在肝脏局部结节性病变诊断中的应用[J].实用放射学杂志，2013，29（5）：776-779.
[22] 饶圣祥，胡道予，宦怡，等.肝胆特异性MRI对比剂钆塞酸二钠临床应用专家共识[J].临床肝胆病杂志，2016， 32（12）：2236-2241.
[23] Löwenthal D，Zeile M，Lim WY，et al. Detection and characterization of focal liver lesions in colorectal carcinoma patients：comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging [J]. Eur Radiol，2011，21（4）：832-840.