|
|
|
| Effect of genistein on fertility of parental rats in the period of mating |
| SUN Xiaoxi ZHANG Yunbo GUO Jipeng NA Xiaolin |
| Public Health College, Harbin Medical University, Heilongjiang Province, Harbin 150081, China |
|
|
|
|
Abstract [Abstract] Objective To explore the effect of genistein on body weight and fertility of parental rats in the period of mating. Methods After adaption for 1 week, 8 weeks female and male SD rats were randomized to 4 groups: high-dose group, middle-dose group, low-dose group and control group, 8 female rats and 4 male rats in each group. Female and male rats were mating at ratio of 2∶1. Different dosage of genistein were given at the beginning of mating fed with high-fat diet for 3 weeks. The high, meddle and low dose groups were given 5400, 1800, 600 mg genistein into every kg fodder diet respectively. No genistein was added in control group. Body weight was weighted every week. The organ weights of male and female rats were weighted, the sperm density of male rats and pragnancy rate of female rats were observed at the end of experiment. Results Compared with control group, body weight of female rats in high-dose group decreased, the difference was statistically significant (P < 0.05). Meanwhile, the sperm density of male rats and pregnancy rate of female rats reduced in high-dose genistein group. Conlusion Genistein can reduce fertility of parental rats in the period of mating.
|
|
|
|
|
|
[1] Varinska L，Gal P，Mojzisova G，et al. Soy and breast cancer：focus on angiogenesis [J]. Int J Mol Sci，2015，16（5）：11728-11749.
[2] Vahid F，Zand H，Nosrat-Mirshekarlou E，et al. The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases：a review [J]. Gene，2015，562（1）：8-15.
[3] 李翀，唐纯娜，贺更生.金雀异黄素抑制肝癌干细胞样细胞的特性及对氟尿嘧啶耐药性的影响[J].海南医学，2015， 26（8）：1108-1111.
[4] 刘润，郭超，赵英.金雀异黄素诱导K562和K562／ADM细胞的凋亡作用[J].中国老年学杂志，2014，34（9）：2516-2518.
[5] 马莹莹，张育，许金鑫，等.金雀异黄素对CIA大鼠促炎和抗炎因子分泌的影响[J].实用药物与临床，2014，17（10）：1247-1249.
[6] 于尚誉，封云，王晓霞，等.大豆异黄酮对育成期蛋用种公鸡生殖激素分泌的影响[J].中国农学通报，2014，30（35）：54-58.
[7] 范觉鑫，张彬，李丽立，等.大豆异黄酮对雄性香猪生殖器官发育及组织生化指标的影响[J].浙江大学学报：农业与生命科学版，2012，38（4）：477-484.
[8] Spagnuolo C，Russo GL，Orhan IE，et al. Genistein and cancer：current status，challenges，and future directions [J]. Adv Nutr，2015，6（4）：408-419.
[9] Samadi AK，Bilsland A，Georgakilas AG，et al. A multi-targeted approach to suppress tumor-promoting inflammation [J]. Semin Cancer Biol，2015，35（Suppl）：S151-S184.
[10] Casey SC，Amedei A，Aquilano K，et al. Cancer prevention and therapy through the modulation of the tumor microenvironment [J]. Semin Cancer Biol，2015，2015，35（Suppl）：S199-S223.
[11] Kishida T，Mizushige T，Ohtsu Y，et al. Dietary soy isof lavone-aglycone lowers food intake in female rats with and without ovari-ectomy [J]. Obesity （Silver Spring），2008，16（2）：290-297.
[12] Zhang YB，Zhang Y，Li LN，et al. Soy isoflavone and its effect to regulate hypothalamus and peripheral orexigenic gene expression in ovariectomized rats fed on a high-fat diet [J]. Biomed Environ Sci，2010， 23（1）：68-75.
[13] Caceres S，Pea L，Moyano G，et al. Isoflavones and their effects on the onset of puberty in male Wistar rats [J]. Andrologia，2015，47（10）：1139-1146.
[14] Zhang Y，Na X，Zhang Y，et al. Isoflavone reduces body weight by decreasing food intake in ovariectomized rats [J]. Ann Nutr Metab，2009，54（3）：163-170.
[15] Naaz A，Yellayi S，Zakroczymski MA，et al. The soy isof lavone genistein decreases adipose deposition in mice [J]. Endocrinology，2003，144（8）：3315-3320.
[16] Kim HK，Nelson-Dooley C，Della-Fera MA，et al. Enistein decreases food intake，body weight，and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice [J]. J Nutr， 2006，136（2）：409-414.
[17] 袁晓雪，李丽立，肖朝武，等.大豆异黄酮对雄性动物生殖系统的影响[J].大豆科学，2011，30（3）：522-525.
[18] 崔洪斌，迟晓星，李百祥，等.大豆异黄酮对雄性大鼠生殖系统的影响[J].卫生毒理学杂志，2003，17（3）：164-166.
[19] 孙合涛，范奇元，周远忠，等.大豆异黄酮对雄性子代大鼠生殖发育的影响[J].遵义医学院学报，2010，33（5）：421-423.
[20] 代晓曼，郭小虎，安秀峰，等.大豆异黄酮对不同时期子代雄性大鼠生殖性状及ER-β受体表达的影响[J].中华男科学杂志，2012，18（10）：915-919. |
|
|
|
