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| Comparison of the anesthetic effect and hemodynamic changes of Mivacurium Chloride and Cisatracurium Besylate in ear-nose-throat surgery |
| ZHANG Xiaodong WANG Huiming QI Jiao SHANG Ying WEN Jing |
| Department of Anesthesiology, the Second Hospital of Baoding, Hebei Province, Baoding 071000, China |
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Abstract Objective To compare the anesthetic effect and hemodynamic changes of Mivacurium Chloride and Cisatracurium Besylate in ear-nose-throat surgery. Methods From January 2017 to January 2018, 80 patients with planed operation of ear, nose and throat under general anesthesia in the Second Hospital of Baoding were divided into observation group and control group according to random number table, 40 cases in each group. Patients were given muscle relaxants for general anesthesia induction, and the control group was given the Cisatracurium Besylate, the observation group was given Mivacurium Chloride. The MAP, HR, SpO2, BIS and four TOF value at seven time points of the home invasion (T1), anesthetic induction immediately (T2), intubation (T3), end of the surgery (T4), consciousness recovery (T5), tube drawing (T6), leaving the room (T7) were recorded. The time of recover, open eyes, extubation, and the restlessness and complications of patients were recorded. Results There were no significant differences in MAP, HR, and SpO2 between the two groups from T1 to T7 (P > 0.05). Compared with T1 and T2 of the same group, the levels of SpO2 in the control group at T5, T6 and the observation group at T7 decreased, and the differences were statistically significant (P < 0.05). Compared with the control group, the BIS values at T4, T7 and the TOF values at T4 to T7 were increased in the observation group, and the differences were statistically significant (P < 0.05); the BIS and TOF values of other time points between two groups were not statistically significant (P > 0.05). Compared with T1 and T2 of the same group, TOF values of T4, T5, T6, T7 in the control group and T4, T5, T6 in the observation group decreased, and the BIS of T3, T4, T5 in the two groups decreased and the differences were statistically significant (P < 0.05). The time of recovery, open eyes, extubation in observation group were shorter than those in control group, the incidence of extubation after agitation and complications was lower than those in control group, the differences were statistically significant (P < 0.05). Conclusion The effects of Mivacurium Chloride on hemodynamics perioperative anesthesia is small, work quickly, short induction time, fast recovery of muscle contraction function, and without the effect of neuromuscular blockade accumulation, it has less postoperative muscle relaxant residual, and is suitable for the ear, nose and throat surgery, safe and effective, which is worth popularizing clinically.
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