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| Anti-N-methyl-D-aspartate receptor encephalitis combined with mediastinal teratoma: a case report and literature review |
| TANG Yao1 WANG Huan1 HUANG Fengqin1 LUO Xingmei2 |
1.Graduate School, Guizhou Medical University, Guizhou Province, Guiyang 550000, China;
2.Integrated Ward, Affiliated Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550000, China
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Abstract Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a complex autoimmune neuropsychiatric syndrome. Previous literature has reported that anti-NMDAR encephalitis is associated with female ovarian teratoma, however, anti-NMDAR encephalitis combined with mediastinal teratoma is rare. The clinical characteristics are not clear, and the treatment has certain limitations. This article present a 14-year-old male patient with anti-NMDAR encephalitis and mediastinal teratoma. During the course of the disease, there were persistent convulsions of the limbs and involuntary movements around the mouth. Hormone shock therapy, plasma exchange, proglobulin, rituximab, and a variety of antiepileptic drugs were used in combination, poor effect. Resection of mediastinal teratoma, condition improved after discharge. In this paper, the pathogenesis, clinical manifestations, and treatment of anti-NMDAR encephalitis complicated with teratoma were reviewed based on medical records and literature, in order to improve clinicians’ awareness of this disease.
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