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| Effect of continuous pump injection of Methoxamine Hydrochloride Injection assisted intravenous-inhalation combined general anesthesia on intraoperative hemodynamics and stroke work in elderly patients with transcervical fracture |
| SU Han1 LEI Jinlai2 |
1.Department of the Second Surgical Anesthesia, Xi′an Red Conference Hospital, Shaanxi Province, Xi′an 710053, China;
2.Department of Traumatic Pelvic, Xi′an Red Conference Hospital, Shaanxi Province, Xi′an 710053, China |
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Abstract Objective To explore the effect of continuous sputum injection of Methoxamine Hydrochloride Injection assisted intravenous-inhalation combined with general anesthesia on intraoperative hemodynamics and stroke work in elderly patients with transcervical fracture. Methods From February 2017 to February 2018, 82 patients with transcervical fracture treated by hip arthroplasty in Xi′an Red Conference Hospital were selected and divided into the control group (n = 41) and the observation group (n = 41) by the random number table method. Both groups were treated with intravenous-inhalation combined general anesthesia. The control group was given continuous infusion of normal saline before induction of anesthesia, and the observation group was given continuous pump injection of Methoxamine Hydrochloride Injection before induction of anesthesia. The hemodynamic parameters including mean arterial pressure (MAP), heart rate (HR) at the time of 5 min before anesthesia induction (T0), endotracheal intubation (T1) and 5 min (T2) and 15 min (T3) after trachea cannula, and the cardiac performance index including left ventricular beats (LVSW), stroke index (SVI) at the end of anesthesia induction and at the end of operation of two groups were compared. And the adverse reactions of two groups were compared. Results There was no significant difference between two groups in MAP and HR at T0 (P ＞ 0.05). There was no significant difference in MAP and HR at T1, T2 and T3 compared with those at T0 in the observation group (P ＞ 0.05). The MAP at T1, T2 and T3 of observation group was higher than that of control group, while HR was lower than that of control group (P ＜ 0.05). The LVSW and SVI of the observation group were lower than those of the control group at the end of anesthesia induction and at the end of operation (P ＜ 0.05). The incidence of adverse reactions in the observation group was 9.76%, lower than 29.27% in the control group (P ＜ 0.05). Conclusion Continuous pump injection of Methoxamine Hydrochloride Injection assisted intravenous-inhalation combined general anesthesia in treating elderly patients with transcervical fracture can stabilize hemodynamics in patients and reduce cardiac work, reduce the occurrence of adverse reactions such as hypotension and tachycardia.
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