视网膜中央静脉阻塞患者血清同型半胱氨酸水平变化及其与血管内皮功能的关系研究

doi:10.20047/j.issn1673-7210.2023.18.25

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Abstract Objective To analyze the changes of serum homocysteine (Hcy) level and its relationship with vascular endothelial function in patients with central retinal vein occlusion (CRVO). Methods A total of 120 patients with CRVO admitted to the Department of Ophthalmology of the First Hospital of Zhangjiakou City of Hebei Province (hereinafter referred to as “our hospital”) from January 2020 to January 2022 were selected as the observation group, and 115 healthy eye subjects from the physical examination center of our hospital from January 2020 to January 2022 were selected as the comparison group. The levels of serum Hcy, blood lipid indexes, nitric oxide (NO), and endothelin-1 (ET-1) were detected and compared between the two groups. According to the results of serum Hcy examination, the observation group was further divided into severe elevation group (26 cases) (＞100 μmol/L), moderate elevation group (50 cases) (30-100 μmol/L), and mild elevation group (44 cases) (16-＜30 μmol/L). The blood lipid indexes, NO, and ET-1 levels of the three groups were compared. Pearson correlation coefficient was used to analyze the relationship between serum Hcy and blood lipid indexes, NO, and ET-1 in the observation group. Results The serum Hcy, ET-1, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) in the observation group were higher than those in the comparison group, and the high-density lipoprotein cholesterol (HDL-C) and NO were lower than those in the comparison group, and the differences were statistically significant (P＜0.05). The levels of ET-1, LDL-C, TC, and TG in the severe elevation group were higher than those in the moderate and the mild elevation group, and the levels of HDL-C and NO were lower than those in the moderate and the mild elevation group, and the differences were statistically significant (P＜0.05). The levels of ET-1, LDL-C, TC, and TG in the moderate elevation group were higher than those in the mild elevation group, and the levels of HDL-C and NO were lower than those in the mild elevation group, and the differences were statistically significant (P＜0.05). In the observation group, serum Hcy was positively correlated with ET-1, LDL-C, TC, and TG (r＞0, P＜0.05), and negatively correlated with HDL-C and NO (r＜0, P＜0.05). Conclusion The serum Hcy level of CRVO patients is significantly higher than that of healthy people, and the serum Hcy level is correlated with blood lipids and the degree of vascular endothelial function damage.

Key words： Central retinal vein occlusion Homocysteine Blood lipids Vascular endothelial function

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	MA Nan HE Jing▲ HUO Hong FAN Hongfang WANG Shuzhen HOU Liping ZHANG Jie

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MA Nan HE Jing▲ HUO Hong FAN Hongfang WANG Shuzhen HOU Liping ZHANG Jie. Study of changes of serum homocysteine level in patients with central retinal vein occlusion and its relationship with vascular endothelial function[J]. 中国医药导报, 2023, 20(18): 112-115.

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https://www.yiyaodaobao.com.cn/EN/10.20047/j.issn1673-7210.2023.18.25 OR https://www.yiyaodaobao.com.cn/EN/Y2023/V20/I18/112

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