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| Effects of different doses of Dexmedetomidine on Morphine consumption in patients with frequent angina before coronary artery bypass grafting |
| WANG Yuanyuan1 HU Haijuan2 LIU Lei1 LI Bin1 LI Zhaobin1 |
1.Department of Cardiac Surgery, the Third Hospital of Hebei Medical University, Hebei Province, Shijiazhuang 050051, China;
2.Department of Cardiovascular, the Second Hospital of Hebei Medical University, Hebei Provincial Cardiovascular Research Institute, Hebei Province, Shijiazhuang 050051, China |
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Abstract Objective To investigate the effect of different doses of Dexmedetomidine (Dex) on Morphine consumption in patients with frequent angina before coronary artery bypass grafting. Methods A total of 100 patients undergoing coronary artery bypass grafting in the Third Hospital of Hebei Medical University from January 2016 to January 2018 were selected. They were divided into group C, Dex 1 group, Dex 2 group, Dex 3 group, by random number table method, 25 cases in each group. The group C was given the 0.1 mg/kg load of Morphine intravenously at the time of angina pectoris; the Dex group was treated with different doses of Dex [Dex 1 group with 0.2 μg/(kg·h), Dex 2 group with 0.5 μg/(kg·h), Dex 3 group with 0.7 μg/(kg·h)], and on the basis of the patients′ angina pectoris condition, the amount of 0.1 mg/kg load was given. Intravenous injection of morphine. Before (T0) and 1 h (T1), 3 h (T2), 6 h (T3), 12 h (T4), 24 h (T5) after the heart rate (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2), total frequency of angina pectoris, Morphine dosage and Ramsay score were recorded. Results The HR at T2-T5, Morphine dosage, and frequency of angina pectoris of Dex group were lower than group C (P < 0.05). From T0 to T5, MAP, RR, SpO2 in each groups had no statistically significant difference (P > 0.05), HR at T2-T5, Morphine dosage, frequency of angina pectoris of Dex 3 group were lower than Dex 1 group (P < 0.05), but, there was no difference between Dex 1 group and Dex 2 group (P > 0.05). From T2 to T5, Ramsay score of Dex 3 group was higher than Dex 1 group and Dex 2 group significantly (P < 0.05). Conclusion Continuous administration of a small dose of Dex [0.2 μg/(kg·h)] to patierts with frequent angia before coronary artery bypass grafting can effectinely control the onset of angina pectories.
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