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| Research advances in the role of pyroptosis in neonatal hypoxic-ischemic encephalopathy |
| HUANG Runzhi1 CAO Changqing2 LI Yuning2 |
1.The First Clinical Medical College, Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Department of Pediatric, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China
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Abstract Hypoxic-ischemic encephalopathy （HIE） is the leading cause of disability and death in neonatal, which has been a major health concern worldwide. At present, there is still a lack of satisfactory treatment for HIE, which is a great threat to children’s health and quality of life. Mutiple researches have shown that the activation and diffusion of inflammation is the main reason for the occurrence and development of HIE. Pyroptosis is a relatively recently described mechanism of inflammatory cell death that is closely related to HIE. The study on pyroptosis and HIE is increasing year by year. This paper summarizes the pivotal role of pyroptosis in HIE and analysis the related mechanisms to provide a basis for future research.
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