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| Advances in the interaction of Dax1 with embryonic stem cells multipotential network factors Oct4, Sox2, Nanog, and Esrrb |
| SUN Huilin YANG Dan HU Zhe▲ |
| Department of Anesthesiology, the Affiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524001, China |
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Abstract The self-renewal and pluripotency of embryonic stem cells (ESCs) are maintained by the large and complex interconnected transcriptional regulatory network formed by transcription factors such as Oct4, Sox2, Nanog, and Esrrb, and Dax1 can also participate in the regulation of ESCs. Dax1 interacts with core factors such as Oct4, Sox2, Nanog and Esrrb, and participates in maintaining characteristics of ESCs and inhibiting ESCs differentiation. Dax1 can also produce a similar promotion to Nanog in the later stages of induction of induced pluripotent stem cells (IPSCs). To study the role, function, status and interaction of Dax1 in the ESCS transcriptional regulatory network and the induction of IPSCs, and the specific mechanisms of interaction with other transcription factors can be helpful for stem cell mechanism research and clinical therapeutic transformation research. At present, there are few studies on the role of Dax1 in embryonic stem cells. This paper reviews the existing research results in order to provide reference for further research and clinical treatment transformation of embryonic stem cells.
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