同型半胱氨酸、红细胞体积分布宽度、糖化血红蛋白变异指数对糖尿病足发生的影响及预测价值

doi:10.20047/j.issn1673-7210.2023.15.15

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Abstract Objective To explore the influence and predictive value of homocysteine (Hcy), red blood cell volume distribution width (RDW), and glycosylated hemoglobin variation index (HGI) on the occurrence of diabetes foot (DF). Methods A total of 166 patients with type 2 diabetes mellitus (T2DM) admitted to the Department of Endocrinology, the Second Affiliated Hospital of Xi’an Jiaotong University from June 2018 to June 2020 were selected and divided into T2DM group (104 cases) and DF group (62 cases) according to whether they had DF or not. Clinical data, Hcy, and RDW levels of the two groups were collected, and HGI was calculated. The influencing factors of DF occurrence were analyzed by binary logistic regression model, receiver operating characteristic (ROC) curve was drawn and area under the curve (AUC) was calculated, and the predictive index and their value of DF were analyzed. Results Age, glycosylated hemoglobin, fasting blood glucose (FBG), Hcy, RDW, and HGI in DF group were higher than those in T2DM group, and the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that FBG, Hcy, RDW, and HGI were independent influencing factors of DF occurrence (P＜0.05). The ROC curve analysis results showed that FBG, Hcy, RDW, and HGI had certain predictive value for DF alone and in combination, the AUC of combination of each index was higher than that of each single prediction (P＜0.05). Conclusion The combined prediction of FBG, Hcy, RDW, and HGI can be an effective predictor of DF treatment and nursing intervention in T2DM patients.

Key words： Type 2 diabetes mellitus Diabetes foot Homocysteine Red blood cell volume distribution width Glycosylated hemoglobin variation index

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	ZHANG Lin1 LONG Junhong1 HUANG Lili1 TIAN Jingyu1 GAO Fei1 LI Youfang2

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ZHANG Lin1 LONG Junhong1 HUANG Lili1 TIAN Jingyu1 GAO Fei1 LI Youfang2. Influence and predictive value of homocysteine, red cell volume distribution width, and glycosylated hemoglobin variation index on the occurrence of diabetic foot[J]. 中国医药导报, 2023, 20(15): 73-76.

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