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| Research progress on pericyte-endothelial cell Crosstalk in micro angiogenesis after myocardial ischemia |
| LIU Yixuan1 TANG Kaixuan2 LI Yitong1 ZHOU Xuancheng2 LIU Yiran1 LI Chao3 |
1.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China;
2.College of Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China;
3.Institute of innovation in Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China
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Abstract Cardiovascular disease is a world public health problem and one of the main causes of human death. Therapeutic angiogenesis can effectively alleviate myocardial ischemia injury and improve cardiac function, which has become an important supplementary treatment strategy after myocardial ischemia. The regulation mechanism of pericyte-endothelial cell Crosstalk on micro angiogenesis after myocardial ischemia mainly includes pericyte contact with endothelial cells through vascular basement membrane and paracrine regulation. Paracrine regulation plays an important role in stabilizing blood vessel/blood system, and improving cardiac function by promoting angiogenesis cytokines, and activating various signal pathways to promote angiogenesis and maturation. Therefore, pericyte-endothelial cell Crosstalk is the key link of micro angiogenesis after myocardial ischemia. This paper reviews the mechanism and role of pericyte-endothelial cell Crosstalk in micro angiogenesis after myocardial ischemia in order to provide ideas for complementary treatment of myocardial ischemia.
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